Fecal transplant for steroid-resistant gut GVHD
Treatments studied
Part of Immune system & allergy clinical trials.
This study tests if a fecal transplant (transferring healthy bacteria from a donor's stool into your gut) can help people with severe gut graft-versus-host disease that hasn't responded to steroids. It's for patients who have had a stem cell transplant and now have ongoing, severe gut symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe gut graft-versus-host disease (GVHD) that didn't get better with steroids, causing more than 5 diarrhea episodes a day or belly pain.
- You are at least 18 years old.
- Your infection-fighting cells (neutrophils) are above 500 and your platelets are above 30,000.
- You can stop taking certain antibiotics for at least 12 hours before the procedure (antiviral and antifungal meds are okay).
- You do not have an out-of-control infection or unstable vital signs (like very low blood pressure or trouble breathing).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether restoring healthy gut bacteria using a fecal microbiota transplant can improve steroid-refractory gut graft-versus-host disease (aGvHD) after stem cell transplant. If your gut symptoms are your first episode and your stool bacteria diversity is low, this trial may be an option worth screening for.
This trial tests whether transplanting healthy gut bacteria can help children whose bodies are rejecting donor stem cells in their intestines and who haven't responded to high-dose steroids. The goal is to reduce intestinal damage and improve outcomes after bone marrow transplant.
This Phase 1 study tests whether a fecal microbiota transplant (a stool-based treatment from a screened donor) plus a dietary fiber supplement can improve gut symptoms after a bone marrow transplant. It is aimed at people with mild to severe gut graft-versus-host disease (GVHD).
This study tests whether transplanting healthy donor stool into the gut can help children and young adults with ongoing digestive issues after a stem cell transplant. It may improve symptoms like diarrhea or the need for feeding tubes.
This study tests whether a fecal transplant (FMT) can help treat gut graft-versus-host disease (gut GVHD), a condition where donated immune cells attack the intestines. If you have gut GVHD and meet age requirements, you may be eligible to receive this treatment in the trial.
This Phase 2 study tests whether a fecal microbiota transplant (a processed transplant of gut bacteria) after an allogeneic bone marrow transplant is safe and helpful. Participants may benefit by improving recovery in the gut microbiome during the post-transplant period.
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