Fecal transplant for steroid-resistant gut graft-versus-host disease
Treatments studied
Part of Immune system & allergy clinical trials.
This trial tests whether giving a fecal transplant (a procedure that transfers healthy bacteria from a donor's stool into your gut) can help children whose gut graft-versus-host disease (a common complication after a stem cell transplant) is not improving with standard steroid treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a blood or bone marrow disease (like leukemia or lymphoma).
- You had a stem cell transplant (bone marrow transplant) from a family member or unrelated donor.
- You have severe graft-versus-host disease (GVHD) with gut symptoms that hasn't responded to steroids.
- You are not currently being treated with antibiotics for a bacterial infection.
- You don't have severe mouth sores or a history of chronic inflammatory bowel disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether restoring healthy gut bacteria using a fecal microbiota transplant can improve steroid-refractory gut graft-versus-host disease (aGvHD) after stem cell transplant. If your gut symptoms are your first episode and your stool bacteria diversity is low, this trial may be an option worth screening for.
This study tests if a fecal transplant (transferring healthy bacteria from a donor's stool into your gut) can help people with severe gut graft-versus-host disease that hasn't responded to steroids. It's for patients who have had a stem cell transplant and now have ongoing, severe gut symptoms.
This study tests whether a fecal microbiota transplant (a procedure that puts healthy donor bacteria into your gut) combined with a dietary fiber supplement can help treat gut graft-versus-host disease, a common complication after a stem cell transplant. It may help reduce diarrhea and other gut symptoms.
This study tests whether a fecal transplant (FMT) can help treat gut graft-versus-host disease (gut GVHD), a condition where donated immune cells attack the intestines. If you have gut GVHD and meet age requirements, you may be eligible to receive this treatment in the trial.
This study tests whether transplanting healthy donor stool into the gut can help children and young adults with ongoing digestive issues after a stem cell transplant. It may improve symptoms like diarrhea or the need for feeding tubes.
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