Melatonin to help prevent kidney damage from vancomycin
Treatments studied
Part of Kidney & urinary, Women’s health & pregnancy clinical trials.
This Phase 3 study tests whether melatonin can help protect the kidneys in people who are starting or continuing vancomycin, an antibiotic that can sometimes affect kidney function. If you qualify, you would take melatonin as an added prevention step while you’re on vancomycin.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 75 years old
- Be currently being treated with vancomycin and expected to stay on it for at least 3 days
- Have kidney filtration (creatinine clearance) estimated at 30 mL/min or higher
- Not have severe liver problems (liver enzymes more than 3 times the usual upper limit)
- Be able to take pills by mouth and not require a breathing machine (mechanical ventilation)
- Not be pregnant or breastfeeding, and not have a melatonin allergy or a condition that makes you unable to take melatonin
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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