Medicine for headache after a labor spinal needle
Treatments studied
Part of Brain & nervous system clinical trials.
This Phase 2 study tests neostigmine plus glycopyrrolate to treat a specific type of severe headache that happens after a dural puncture during labor. If you have a new headache starting within 72 hours of delivery and no other cause, this treatment may help relieve your pain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had an epidural labor procedure where the covering of the spinal canal was punctured (a dural puncture) with a Tuohy needle
- Your headache started within 72 hours after delivery
- Your headache is severe enough: your pain score must be 4 or higher
- You do not have a history of migraine headaches
- You can understand and complete pain scores and questionnaires and speak English
- You have not already had an EBP (epidural blood patch) for this same headache
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial compares two treatments for the severe headache that can occur after a spinal tap or epidural. One treatment is a numbing medicine sprayed into the nose (sphenopalatine block), the other is a blood patch (injecting your own blood into your back). The goal is to see which works better and faster.
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