Surgery versus chemoradiation for tonsil and tongue-base cancer
Part of Cancer clinical trials.
This trial compares two standard treatments for a type of throat cancer (oropharyngeal cancer) that has not spread to distant organs. Patients will be randomly assigned to either surgery or a combination of chemotherapy and radiation, to see which approach offers better outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with squamous cell carcinoma of the tonsil or the base of the tongue.
- Your cancer is at stage III or IV but has not spread to distant organs.
- Your cancer is HPV-negative (a specific test will confirm this).
- You are between 18 and 70 years old and are fit enough to undergo surgery or chemoradiation.
- You have adequate organ function (kidney, liver, blood counts) and no contraindications to cisplatin chemotherapy.
- You have not had prior head or neck cancer, and you have not received chemotherapy or radiation to the head or neck before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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