Compare surgery vs chemoradiation for HPV-negative throat cancer
Part of Cancer clinical trials.
This trial compares two standard treatment approaches for oropharyngeal (throat) squamous cell cancer: surgery plus recovery, versus chemotherapy combined with radiation. It is testing which plan works better for patients whose tumors are HPV-negative (p16 negative).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have throat cancer in the oropharynx (tonsil and/or the side of the tongue base) confirmed by biopsy
- Your cancer is HPV-negative (p16 test is negative)
- The tumor can be removed completely with surgery (surgeon believes clear margins are possible), and it is not inoperable
- Your disease is stage III or IV but does not have spread below the collarbone
- You must be able to have general anesthesia and your general health score is 0–2
- Your blood counts, liver, and kidney tests are strong enough for cisplatin chemotherapy and radiation
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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