Radiation plus chemo choices for throat cancer, using a tumor marker
Part of Cancer, Ear, nose & throat, Lungs & breathing clinical trials.
This trial compares two treatment combinations given with radiation for certain cancers of the throat. It also uses a lab test on the tumor (ERCC1) to help choose and study which treatment works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed cancer of the oropharynx, larynx, or hypopharynx (throat area) that has not spread to distant organs.
- Your cancer is stage III or IV (IVA or IVB), based on recent scans and a head-and-neck exam.
- You have not had prior chemotherapy, targeted medicines, or radiation for head and neck cancer.
- A tumor biopsy sample is available for ERCC1 testing, and you can consent to mandatory extra tissue testing.
- You must be well enough for treatment (generally age 18+, and certain blood, kidney, liver, and mineral levels must be adequate).
- If you are able to become pregnant, you must use reliable birth control and not be pregnant; this also applies to men.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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