Radiation vs mouth surgery for HPV-negative throat cancer
Part of Cancer clinical trials.
This Phase 2 trial compares two standard cancer treatments—radiation or surgery through the mouth—for HPV-negative oropharyngeal throat cancer. It aims to find out which approach works better while keeping side effects and quality of life acceptable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older and can sign informed consent
- Your cancer is squamous cell carcinoma and is in the oropharynx (tonsil/soft palate/base of tongue/throat area)
- Your tumor is HPV-negative based on lab testing (p16 and/or PCR or tissue hybridization); uncertain results may still be allowed
- Your cancer is early to limited (T1–T2) and may be curatively treated, with a plan for clear (negative) surgery margins
- Your cancer is not metastatic (it has not spread to distant sites)
- You can do treatment and follow-up, and you can complete quality-of-life questionnaires
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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