Surgery then lower-dose radiation for p16+ throat cancer
Treatments studied
Part of Cancer, Ear, nose & throat, Infections, Mouth & dental clinical trials.
This Phase 2 study tests whether removing the tumor through the mouth, followed by a reduced course of radiation, can control HPV-related (p16+) oropharynx throat cancer. It may help reduce treatment intensity after surgery, while still aiming to keep the cancer from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have newly diagnosed oropharynx (throat) cancer confirmed on biopsy, and it can be surgically removed
- Your cancer is p16-positive (a lab test on tumor tissue that suggests HPV involvement)
- Your scans show no spread to distant organs (no distant metastasis)
- You have good physical strength/health scores (ECOG 0–1 or Karnofsky 80–100)
- You have no major prior radiation above the collarbone area
- You can safely have surgery through the mouth without needing a free-flap reconstruction
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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