Clin2
NCT05151588Possibly a fitNot yet recruiting

Chemotherapy plus tazemetostat for advanced nasal cancer

Sinonasal Carcinoma

Treatments studied

Part of Cancer, Ear, nose & throat clinical trials.

This trial tests a combination of chemotherapy and a targeted drug called tazemetostat for a rare type of nasal cancer that has not spread. The goal is to see if this combination can shrink the tumor and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older and weigh at least 40 kg.
  • You have a confirmed diagnosis of locally advanced SMARCB1-deficient sinonasal carcinoma (a rare nasal cancer).
  • Your cancer has not spread to other parts of the body.
  • You have not had certain cancer treatments within the last few weeks (varies by type).
  • Your blood counts, liver, and kidney function are within acceptable levels.
  • You are willing to use effective contraception if you or your partner can have children.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07522879Recruiting· Phase 2
Testing a new drug combo for recurrent sinus cancer

This trial tests whether combining the targeted drug becotatug vedotin with chemo can shrink recurrent adenoid cystic sinus tumors that can't be fully removed by surgery. It's for people whose tumors have a specific protein called EGFR.

Shanghai
NCT07652489Recruiting
Surgery plus radiation for advanced sinus cancer

This study looks at whether surgery followed by radiation helps people with a specific type of sinus cancer called adenoid cystic carcinoma that has grown into nearby tissues. It aims to see how well this treatment works and how safe it is.

Harbin, Heilongjiang
NCT05027633Recruiting· Phase 2
Immunotherapy plus chemo and radiation for nasal cancer

This Phase 2 study tests a treatment plan that combines immunotherapy with chemotherapy and chemoradiation for advanced squamous cell cancer in the nasal cavity or sinuses. It aims to improve cancer control in people who are newly diagnosed and have not had prior treatment for this cancer.

Houston, Texas
NCT07645846Not yet recruiting· Phase 2
Chemotherapy plus double immunotherapy before surgery for sinonasal cancer

This trial tests a combination of chemotherapy (docetaxel and cisplatin) plus two immunotherapy drugs before surgery for people with newly diagnosed, locally advanced sinonasal cancer. The goal is to see if this combination helps shrink the tumor and improves the chance of successful surgery.

NCT06940180Recruiting· Phase 2
Immunotherapy and chemotherapy before surgery for sinus cancer

This trial tests a combination of an immunotherapy drug (toripalimab) plus chemotherapy before surgery for sinus cancer that has not spread. The goal is to see if this treatment shrinks the tumor so surgery can be more effective.

Boston, Massachusetts
NCT05925491Recruiting· Phase 2
Pembrolizumab for locally advanced nasal cavity cancer

This trial tests pembrolizumab (an immune therapy) for locally advanced sinonasal cancer that can still be cured with local treatments. It aims to improve outcomes by helping your immune system better fight the tumor.

Pavia, Lombardy

Hear when a new Sinonasal Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.