Chemo plus dual immunotherapy before surgery for sinus cancer
Treatments studied
Part of Cancer, Ear, nose & throat clinical trials.
This trial tests whether combining chemotherapy with two immunotherapy drugs (PD-1 inhibitors) before surgery can improve outcomes for patients with advanced sinonasal carcinoma. It aims to shrink the tumor before removal.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are newly diagnosed with stage III to IVA sinonasal carcinoma.
- You are between 18 and 75 years old.
- Your daily activities are not significantly limited (ECOG score 0 or 1).
- Your blood counts, kidney, and liver functions are within certain ranges.
- You have not had prior treatment with PD-1 or similar immunotherapy drugs.
- You agree to use effective birth control during and for 3 months after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of an immunotherapy drug (toripalimab) plus chemotherapy before surgery for sinus cancer that has not spread. The goal is to see if this treatment shrinks the tumor so surgery can be more effective.
This trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy before surgery helps treat sinonasal squamous cell carcinoma. The goal is to see if this combination reduces tumors more effectively than chemotherapy alone.
This study looks at whether surgery followed by radiation helps people with a specific type of sinus cancer called adenoid cystic carcinoma that has grown into nearby tissues. It aims to see how well this treatment works and how safe it is.
This trial tests two cancer drugs (anlotinib and epirubicin) given before surgery to shrink advanced adenoid cystic carcinoma tumors in the sinuses. The goal is to make surgery safer and more effective for tumors that have grown into nearby structures like the skull base or eye socket.
This Phase 2 study tests a treatment plan that combines immunotherapy with chemotherapy and chemoradiation for advanced squamous cell cancer in the nasal cavity or sinuses. It aims to improve cancer control in people who are newly diagnosed and have not had prior treatment for this cancer.
This study tests a new combination of an immunotherapy drug (AK112) with chemotherapy before surgery for advanced head and neck cancer. The goal is to see if this approach can shrink tumors and improve outcomes for patients who have not been treated before.
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