Oncolytic virus treatment for recurrent brain tumors after surgery
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This early-phase study tests an oncolytic virus—an anti-cancer virus—given into the brain to treat recurrent brain tumors after surgery. It aims to shrink tumors or slow their growth by directly targeting cancer cells in the brain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 or older and can give informed consent
- Your brain tumor has been confirmed by pathology and is coming back after surgery (Phase II focuses on recurrent glioblastoma)
- You had part or all of the tumor removed, and an Ommaya reservoir was placed for medicine delivery
- The trial drug would be injected into the upper part of the brain (supratentorial area), and you’re expected to live at least 3 months
- Your blood counts and organ tests (liver/kidney) are within required ranges, and clotting tests are acceptable
- You haven’t had certain cancer treatments or brain radiation very recently, and you don’t have active serious infections or known drug allergies
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-stage study tests a virus therapy designed to attack solid tumors that cannot be removed by surgery or have returned/spread. It may help shrink tumors and control cancer in people whose standard treatments are no longer working.
This trial tests a new treatment combining an oncolytic virus with a PD-1 inhibitor for people whose high-grade glioma has come back after standard therapy. The virus is injected directly into the tumor through a device placed in the head, and the drug helps your immune system fight the cancer cells.
This trial tests a new drug, GC001, injected directly into the tumor in people with high-grade gliomas (WHO grade 3 or 4) that have come back or are growing. It may be an option if standard treatments have stopped working.
This trial tests a virus-based treatment for people with advanced solid tumors that haven't responded to standard treatments. The virus is designed to infect and kill cancer cells while leaving healthy cells alone.
This trial tests a modified virus that may help treat a type of brain cancer called high-grade glioma. It is for patients who have not yet had any treatment for their tumor.
This early-phase trial tests an injection of a virus designed to attack cancer cells in people with advanced solid tumors. It is meant for situations where standard treatments have not worked (or you can’t/won’t take them) and when doctors can directly deliver the treatment to a tumor spot.
Hear when a new Central Nervous System Tumors trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.