Pentosan for bladder irritation after pelvic radiation
Part of Kidney & urinary clinical trials.
This trial studies whether pentosan polysulfate sodium can reduce bladder bleeding (hematuria) and urinary symptoms caused by radiation cystitis after pelvic cancer radiation. It may help people who are still having these bladder problems more than 6 months after radiation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You can sign consent and agree to follow study rules
- You are age 20 or older
- You had cancer radiation to the pelvic area, and it ended more than 6 months ago
- You currently have radiation cystitis with lower urinary symptoms or blood in the urine
- Blood tests must be reasonably normal for liver, kidneys, and blood clotting, and your platelets must be at least 100,000
- No pregnancy, breastfeeding, or planned pregnancy during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new treatment for bladder irritation caused by past radiation therapy. It uses a solution made from stem cells (called exosomes) combined with a natural lubricant, which is placed directly into the bladder. This may help reduce symptoms like frequent urination, urgency, and blood in the urine, improving comfort and quality of life.
This study tests whether putting hyaluronic acid (a natural substance) directly into the bladder can help prevent radiation cystitis (bladder inflammation and pain from radiation) in people receiving radiation and chemotherapy for muscle-invasive bladder cancer. If it works, it may help you tolerate treatment better and keep your bladder healthy.
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms and reduce inflammation in people with bladder damage from past pelvic radiation. It compares patients with radiation cystitis to those without it.
This trial tests an herbal capsule (five-flavor sophora flavescens) to see if it can ease rectal pain, bleeding, and other symptoms caused by radiation therapy to the pelvic area. The goal is to find a gentler, effective way to manage this common side effect and improve comfort.
This trial tests a combination of a targeted drug (enfortumab vedotin) and focused radiation before surgery to remove the bladder. It aims to improve outcomes for people with bladder cancer that has not spread beyond the bladder.
This trial tests whether adding the immunotherapy drug pembrolizumab to radiation therapy works as well as or better than the usual chemotherapy given with radiation for a type of bladder cancer that has not invaded the muscle. It is for people whose cancer came back or has high-risk features and who would otherwise need to have their bladder removed.
Hear when a new Radiation Cystitis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.