Surgery type for infected heart valve: standard vs special tissue
Part of Heart & circulation clinical trials.
This trial compares two surgical options for people with an infected heart valve: a conventional prosthetic valve versus a cryopreserved (stored) aortic homograft (special donated tissue). It may help surgeons choose the safest option to control infection and prevent complications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your doctors must confirm you have infective endocarditis (a confirmed heart valve infection using Duke criteria).
- You likely have uncontrolled infection or a complication such as an abscess, very large infected area, a false aneurysm, or a leak/opening where the valve was (for example, fistula or dehiscence).
- You may have a high-risk situation with large vegetations (infected clumps) greater than 10 mm and/or ongoing infection, and you may have had embolism (pieces breaking off).
- You may have serious heart strain from the infection affecting the aortic root or nearby structures, or signs like fluid in the lungs or low blood pressure/shock.
- You must have evidence on an echocardiogram (ultrasound of the heart) that the infection is present—if the echo shows no infection, you can’t join.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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