TAVR vs surgery for narrowed aortic valve
Part of Heart & circulation clinical trials.
This trial compares a less invasive valve procedure called TAVR with standard open-heart surgery to replace a narrowed aortic valve. It studies which approach works best for people who are considered higher risk for surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a narrowed aortic valve causing symptoms and test abnormalities (such as mean gradient over 40, or jet speed over 4.0 m/s, or valve area under 0.8 cm²).
- You are considered high risk for surgical valve replacement (predicted risk of death from surgery about 15% or higher, or a STS score 10 or higher).
- If your STS score is below 10, two surgeons must review your case and agree your predicted surgical risk is still 15% or higher.
- You have no recent heart attack in the past month before the planned treatment.
- You are medically stable enough for the procedure (no severe instability needing strong “push” medicines or a heart machine).
- You can take required blood-thinning medicines like aspirin and heparin, and contrast dye if needed (with no serious allergy that can’t be prevented).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares a less invasive valve replacement (TAVR) with traditional open-heart surgery for people with a specific type of severe aortic valve narrowing (bicuspid valve). It aims to see which approach works better for those at intermediate or low surgical risk.
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This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
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This study compares regular monitoring (“clinical surveillance”) versus replacing the aortic valve using a minimally invasive procedure called TAVR for people with moderate aortic stenosis. It aims to see which approach better reduces symptoms or heart damage over time.
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