Radiation plus chemo after liver surgery for bile duct cancer
Treatments studied
Part of Cancer clinical trials.
This trial studies giving a special internal radiation treatment along with capecitabine (a chemotherapy) for liver cancer related to bile ducts, after planned surgical removal. It may help improve control of the cancer in cases where surgeons think the edges of the removed tumor may be too close.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be over 18 years old
- You must have confirmed intrahepatic cholangiocarcinoma (a specific type of bile-duct liver cancer) from biopsy or surgery
- You should not have had any previous treatment for this bile-duct liver cancer
- Your cancer should be considered removable by a liver surgery specialist, with a high risk of close surgical margins (edges)
- Your blood tests, liver function, kidney function, and clotting must meet safety limits
- You must be able to follow the study plan and provide informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a treatment for intrahepatic cholangiocarcinoma (a type of liver cancer) that can be surgically removed. It combines the usual chemotherapy drugs (cisplatin and gemcitabine) with the immunotherapy drug durvalumab, and compares it to the same regimen plus a targeted therapy called futibatinib, which works on specific genetic changes in the tumor. The goal is to see if adding the targeted therapy helps shrink the tumor before surgery and improves the outcome.
This trial combines a liver-directed radiation therapy (radioembolization) with a targeted drug to treat a specific type of bile duct cancer that cannot be surgically removed. The goal is to see if this combination can shrink the tumor and improve outcomes.
This trial tests whether combining chemotherapy with radiation after surgery can help prevent the return of intrahepatic cholangiocarcinoma, a type of bile duct cancer. It is for people whose surgery showed a narrow margin or cancer in nearby lymph nodes.
This trial is testing a combination of two drugs (one that helps the immune system fight cancer and one that blocks blood vessel growth) with a special chemotherapy given directly into the liver. The goal is to shrink the tumor so it can be removed with surgery, possibly improving the chances of a cure.
This trial tests a combination of chemotherapy directly into the liver artery, an immunotherapy drug, and a targeted therapy pill before surgery for a type of bile duct cancer that has a high chance of coming back. The goal is to see if this approach can improve outcomes for patients whose cancer is still removable but has certain high-risk features.
This trial tests a combination of chemotherapy (gemcitabine and cisplatin) with the targeted therapy lenvatinib and the immunotherapy adebrelimab for people with advanced bile duct cancer that cannot be removed by surgery. It aims to see if this combination works better than standard treatments.
Hear when a new Resectable Intrahepatic Cholangiocarcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.