Clin2
NCT05327478Worth exploringRecruiting

Compare treatments for controlled donation after circulatory death

Liver TransplantOrgan PerfusionComplication of Surgical Procedure

Part of Digestive system clinical trials.

This trial compares different care approaches for adult donors in a specific type of controlled donation after the heart stops. It aims to find which approach best supports organ/tissue use after donation.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
150 people
Ages
50 years to 75 years
Study type
Observational

Who can take part

  • You are a donor in a controlled donation after the heart stops (DCD), specifically Maastricht type III or V
  • Age is over 50 and under 75 years
  • You do not have cancer, unless it is a non-spread (not metastatic) brain/spinal cord tumor, non-melanoma skin cancer, or a cancer that is fully cured
  • No active serious infections are present (for example sepsis, meningitis, HIV, tuberculosis, or certain viral infections)
  • There is no history of intravenous drug abuse
  • In the NRP group, BMI must be 35 or less, and liver enzyme levels (transaminases) must not be above 1000 or improving before donation

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07595627Not yet recruiting
Machine-Preserved Liver Transplants for End-Stage Liver Disease

This trial tests a special preservation machine that keeps donor livers cold and functioning during transport before transplant. The goal is to improve how well donated livers work after transplantation and reduce complications.

São Paulo, São Paulo
NCT07556588Recruiting
Heart transplant study using perfusion technology

This study tests a special machine that helps preserve and evaluate donor hearts before transplant. If you're waiting for a heart transplant, this trial may help doctors find the best donor hearts and improve transplant outcomes.

Leuven
NCT06371924Recruiting
Machine perfusion for livers from donation after circulatory death

This study tests a new way to preserve donated livers (called machine perfusion) after they are recovered from donors who died from circulatory causes. It aims to see if this method helps the liver work better before transplant.

Birmingham
NCT07779187Not yet recruiting
Study comparing two ways to preserve donated kidneys

This trial compares two ways of preserving kidneys from donors after cardiac death before transplanting them into recipients. One method uses a machine that pumps oxygenated fluid through the kidney (called NRP), and the other uses the same method plus an additional oxygen treatment (HMPO2). The goal is to see if the extra treatment improves kidney function after transplant.

Gothenburg
NCT03946852Not yet recruiting
Testing a new blood-boost method for liver transplants after cardiac death

This study tests whether a special way of moving blood through the donor abdomen before surgery can improve liver (and other organ) transplant quality. It may help because doctors can check how well the liver seems to be working before it’s actually used.

NCT06950398Not yet recruiting· Phase 2
Testing discarded livers with machine perfusion

This trial tests if a machine that pumps warm oxygenated blood through livers that were considered unsuitable for transplant can help doctors decide if they are actually safe to transplant. If so, it could increase the number of available livers for people waiting for a first liver transplant.

Clichy

Hear when a new Liver Transplant trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.