Chemo plus targeted high-dose radiation for low rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests whether combining chemotherapy with high-dose radiation guided by MRI (a special scan) can better treat low rectal cancer. It may help shrink the tumor and improve local control while targeting the tumor more precisely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with rectal adenocarcinoma confirmed by tissue testing (biopsy).
- Your rectal tumor is low: the lower edge is 5 cm or less from the anus.
- Your cancer scans/staging suggest no distant spread (M0).
- Your tumor testing shows “MSS/PMMR” (not MSI-high or mismatch-repair deficient).
- You can have MRI (or similar scans used in the treatment planning) and you’re well enough for treatment (performance score 0–1).
- You have not started prior anti-cancer treatment for this cancer (no prior surgery/radiation/chemo/immunotherapy).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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