Short radiation plus chemo with immunotherapy for rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This study compares two treatment approaches for patients with locally advanced rectal cancer. One group gets a short course of radiation followed by chemotherapy combined with an immunotherapy drug called a PD-1 inhibitor, while the other group gets radiation and chemotherapy alone. The trial aims to see if the PD-1 inhibitor improves outcomes and whether a natural substance in the blood called beta-hydroxybutyrate can predict response.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with locally advanced rectal adenocarcinoma, and the lower edge of the tumor is within about 10 cm from the anus.
- You have not yet received any treatment for rectal cancer (like radiation, chemo, or surgery).
- You are generally in good health (able to do daily activities, and your blood counts and organ function are within normal limits).
- Your tumor does not have a certain marker called 'pMMR' (the trial is looking for patients with a different marker).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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