Chemo and radiation for low rectal cancer, aiming to avoid surgery
Part of Cancer, Digestive system clinical trials.
This trial tests whether people with early- to intermediate-stage low rectal cancer can avoid surgery if their tumor responds well to a full course of chemotherapy and radiation. It starts with brief chemotherapy, then adjusts treatment based on how much the tumor shrinks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- Your rectal cancer is a common type (pMMR/MSS) and it's not too advanced (stage T1 to T3b, no spread to distant organs).
- The bottom edge of your tumor is within about 2 inches (5 cm) of the anal opening.
- The tumor is no more than 2 inches long and involves less than two-thirds of the rectum's width.
- You are willing to receive chemotherapy (XELOX), radiation, and more chemotherapy, and then possibly avoid surgery if the tumor disappears.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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