PET/MRI scan to guide treatment in HER2+ brain metastatic breast cancer
Treatments studied
Part of Brain & nervous system, Cancer, Skin clinical trials.
This trial tests a special PET/MRI imaging scan using a labeled drug to help doctors evaluate HER2+ breast cancer that has spread to the brain. It focuses on patients who plan to receive fam-trastuzumab deruxtecan, a targeted cancer medicine, and aims to see how well the scan can support treatment decisions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You can give informed consent (or your legal representative can), and you’re age 18 or older.
- You have HER2-positive metastatic breast cancer that has spread to the brain (brain metastases).
- You can do treatment activities rated ECOG 0–2 (generally: fully active to limited but able to care for yourself).
- Your heart function is good enough for treatment (left ventricular ejection fraction over 50%) and you do not have certain recent or unstable heart problems.
- Your blood counts and organ labs are within limits: ANC > 1.5, platelets > 100, hemoglobin > 9, and kidney/liver tests meet thresholds.
- You’re scheduled to start fam-trastuzumab deruxtecan and you have at least one brain lesion over 1.5 cm on MRI (unless excluded for needing urgent local treatment).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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