Clin2
NCT05377905Possibly a fitRecruiting

Microneedle skin treatment plus doxorubicin for skin cancer

Cutaneous Squamous Cell CarcinomaSkin Cancers - Squamous Cell Carcinoma

Part of Cancer, Skin clinical trials.

This early-phase study tests whether delivering chemotherapy through tiny skin needles (microneedles) can shrink or control cutaneous squamous cell cancer (cSCC) that can be surgically treated. Because it’s Phase 1/2, the main goals are to check safety and find the best way to deliver the treatment.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
48 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have a biopsy-confirmed diagnosis of cutaneous squamous cell cancer (cSCC).
  • Your cancer is in an early stage (stage I–III) that doctors think can be fully removed.
  • The tumor is between 5 mm and 99 mm at its longest measurement after biopsy.
  • You are 18 or older, can understand the consent form, and expect to live at least 12 months.
  • Your general health is in the range called ECOG 0–2 (you can do most daily activities).
  • Your blood tests, kidney/liver tests, and infection status meet specific limits, and you are not on other cancer study treatments.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06875609Recruiting
ctDNA test for skin cancer patients

This trial studies a blood test (ctDNA) in people with a type of skin cancer called cutaneous squamous cell carcinoma. It aims to see if the test can help track the cancer and guide treatment decisions.

Boston, Massachusetts
NCT06288191Recruiting· Phase 2
Nivolumab and relatlimab before surgery for skin cancer

This trial tests if two immunotherapy drugs, nivolumab and relatlimab, given before surgery can help shrink a type of skin cancer called cutaneous squamous cell carcinoma. It's for people whose cancer can be removed with surgery.

Wollstonecraft, New South Wales
NCT06823479Recruiting· Phase 2
Ultra-short immunotherapy before surgery for skin cancer

This trial tests a very short course of immunotherapy (nivolumab) before standard surgery for patients with certain types of advanced or hard-to-treat skin cancer (cutaneous squamous cell carcinoma). The goal is to see if this approach can reduce the need for extensive or disfiguring surgery.

Maastricht, Limburg
NCT07288073Recruiting· Phase 2
TIL Therapy for Advanced Skin Cancer Patients

This study tests a personalized cell therapy called TIL (tumor-infiltrating lymphocytes) for people with advanced skin cancers that have not responded to immunotherapy. Doctors take your tumor cells, grow immune cells from them, and then infuse them back to fight the cancer.

Boston, Massachusetts
NCT03370406Recruiting· Phase 1
Test cream and injection treatment for skin squamous cell cancer

This early-phase study tests whether combining an injection into the skin lesion with a topical cream can treat squamous cell skin cancer. It may help shrink the cancer and improve control in people whose tumor is in the lower legs or feet.

Pittsburgh, Pennsylvania
NCT06782399Enrolling by invitation· Early Phase 1
Drug screening for skin squamous cell cancer lesions

This trial tests a device placed on skin cancer lesions to see which drugs might work best. It is for people with visible squamous cell carcinoma on the skin, including lesions that have come back after radiation.

Boston, Massachusetts

Hear when a new Cutaneous Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.