Clin2
NCT05384158Possibly a fitRecruiting

Testing a computer game for low mood, low pleasure, or anxiety

Neurobehavioral Components of Reward and Loss Valuation

Part of Brain & nervous system, Mental health clinical trials.

This trial looks at how a computer-based task performs when someone is dealing with depression-like symptoms, such as low mood, low interest/pleasure, or anxiety that affects daily functioning. You might find it helpful if you fit their symptom and safety requirements and are comfortable with computer tasks and (for some parts) MRI scanning.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
252 people
Ages
25 years to 50 years
Study type
Interventional

Who can take part

  • You have symptoms of low mood, anxiety, or reduced pleasure that interfere with everyday functioning.
  • You can read and understand English well enough to take part in study tasks.
  • You can use a computer: you can see the screen and complete simple computer games.
  • You do not have a history of seizure disorder.
  • You have not had certain serious brain or hormone issues (like stroke, significant head injury causing more than 10 minutes unconsciousness, or an ongoing hormone disorder).
  • You are not currently pregnant and can safely complete MRI scanning if needed (no MRI contraindications).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06417437Recruiting· Phase 4
Brain-computer interface test for depression

This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.

Shanghai, Shanghai Municipality
NCT04864080Recruiting
Online study to measure brain-related signals in pain or depression

This trial uses an online study platform to look for “cognitive biomarkers,” which are measurable patterns in thinking or brain-related responses. It compares people with pain or depression to healthy controls to see how these patterns differ and could help future research or care.

Minneapolis, Minnesota
NCT06982820Recruiting
Brain training therapy for depression with loss of interest

This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.

Providence, Rhode Island
NCT06546917Recruiting
Cognitive training trial for mild depression with brain scans

This trial tests a computer-based cognitive training program (bWell-D) to see if it can improve thinking skills like memory and focus in people with mild depression. You will also have an MRI brain scan to see how the training affects your brain.

Vancouver, British Columbia
NCT06080646Recruiting
Depression and Reward Processing Brain Study

This study uses brain scans (MRI) to understand how people with depression process rewards, aiming to identify different depression subtypes. You may join if you have depression or if you are a healthy volunteer.

San Francisco, California
NCT06132581Recruiting
Brain stimulation for pleasure loss in depression

This study tests a new type of brain stimulation to see if it can help people with depression who have lost the ability to feel pleasure. It uses MRI scans to guide the treatment and may help improve motivation and goal-setting.

Tallahassee, Florida

Hear when a new Neurobehavioral Components of Reward and Loss Valuation trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.