Oral low-dose chemotherapy for relapsed Wilms tumor
Treatments studied
Part of Cancer, Genetic & congenital, Kidney & urinary, Women’s health & pregnancy clinical trials.
This Phase 1/2 trial studies metronomic (very low, steady) chemotherapy taken by mouth or through a feeding tube for children with Wilms tumor that has come back or not responded to earlier treatment. It aims to shrink measurable tumors with better long-term tolerability than standard chemotherapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age: at least 18 months old and not older than 17 years
- Your Wilms tumor has come back (relapsed) or did not respond (refractory), confirmed by past tumor testing
- You have had at least 2 rounds of chemotherapy (or 1 round in certain high-risk relapse situations) and there is no curative treatment option
- You currently have tumor that can be seen/measured on CT or MRI (or are told it can be evaluated)
- You can take study medicines by mouth or via a nasal/feeding tube, and blood counts and organ tests (liver/kidney) are in acceptable ranges
- You must not be pregnant or breastfeeding, and you (if sexually active) must agree to reliable birth control during treatment and for a few months after stopping
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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