Chemo with paclitaxel, ifosfamide, and cisplatin for high-risk germ cell tumors
Part of Cancer clinical trials.
This Phase 2 trial tests a specific chemotherapy combination (paclitaxel, ifosfamide, and cisplatin) for children and teens with newly diagnosed, high-risk germ cell tumors. It aims to improve outcomes by treating cancer cells with a stronger chemo plan.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age must be over 1 year and under 20 years
- You must have a diagnosed germ cell tumor (confirmed by pathology or cell tests)
- The tumor must be newly diagnosed and not treated with chemotherapy before
- It must be higher than stage II (stage I is not allowed)
- The tumor type must be one of these: embryonal carcinoma, choriocarcinoma, yolk sac tumor, or teratoma with malignant germ cell parts
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of two chemotherapy drugs—teniposide and cisplatin—for people who have just been diagnosed with a malignant germ cell tumor in the brain. The goal is to see if this treatment is safe and effective.
This study looks at how to manage germ cell tumors in children and young adults using careful monitoring for some patients and chemotherapy for others. It aims to see whether these approaches can control the cancer while avoiding unnecessary treatment when possible.
This Phase 3 trial compares two different chemotherapy approaches for women with ovarian sex cord–stromal germ cell tumors. It aims to see which treatment works better and is safer for newly diagnosed stage IIA to IVB disease after surgery.
This trial tests a new combination of chemotherapy drugs (irinotecan, temozolomide, and vincristine) for children whose solid tumors have come back or not responded to standard treatment. It aims to see if a specific gene test can help doctors choose the right dose of irinotecan to reduce side effects.
This trial tests a second-line high-dose chemotherapy for germ cell tumors that have come back after initial treatment. It may be an option for patients whose cancer progressed after 3–4 cycles of standard platinum-based chemo.
This trial tests a combination of chemotherapy drugs (paclitaxel, ifosfamide, cisplatin) and an immunotherapy drug (triplizumab) given before surgery for locally advanced penile cancer. The goal is to shrink the tumor and improve outcomes.
Hear when a new Pediatric Germ Cell Tumor trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.