Clin2
NCT05490134Possibly a fitRecruiting

Testing naloxone for brain effects in healthy adults

Analgesia

Treatments studied

Part of Brain & nervous system clinical trials.

This early study tests a medicine called naloxone, given by the study, to see how it affects the brain and safety in people who are otherwise well. It may help researchers understand naloxone’s potential role in brain-related conditions.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
136 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • Be between 18 and 65 years old
  • Be able to understand the study and sign consent yourself
  • Be able to have an MRI scan (no MRI safety issues)
  • Have no metal implants in the head, heart, or neck, and no past brain surgery
  • Have no recent or untreated major mental health, nervous system, or seizure history

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06251609Not yet recruiting· Phase 2
Naloxone for cardiac arrest linked to drug use

This trial tests whether giving naloxone, a medicine that reverses the effects of opioids, during a cardiac arrest outside the hospital can help save lives. It is for adults whose cardiac arrest may have been caused by opioid use.

San Francisco, California
NCT07459166Recruiting· Phase 2
Testing a new drug for fentanyl overdose

This study tests a new drug, CS-1103, to see if it can safely help reverse the effects of fentanyl (a strong opioid) even after a naloxone block. Healthy volunteers who have used opioids before will be given fentanyl and then the study drug, while researchers monitor safety and how the drug works.

Glendale, California
NCT06666621Recruiting· Phase 4
Naloxone injection for low back pain

This trial tests whether naloxone, a drug that blocks opioid effects, can change how your body responds to pain injections in the lower back. It may help find new ways to treat low back pain that hasn't improved with physical therapy or oral medications.

Nashville, Tennessee
NCT04166071Enrolling by invitation· Early Phase 1
Testing whether opioids plus support change learning behavior

This early study tests how opioid medicine, along with social support, affects how people learn or “unlearn” certain responses. If you’re healthy and meet safety requirements, it may help researchers understand how support could change the effects of pain-related medicines on behavior.

Los Angeles, California
NCT07806565Not yet recruiting· Phase 2/Phase 3
Naloxone for heart stoppage in the hospital

This trial tests whether giving naloxone (a medicine that blocks the effects of opioid drugs) during CPR can improve survival after a cardiac arrest in the hospital. It may help by reversing any opioid-related causes of the cardiac arrest, potentially giving you a better chance of recovery.

NCT05509257Recruiting· Early Phase 1
Naltrexone and brain scans for teens with eating disorders

This early study tests whether naltrexone (a prescription medicine) changes brain activity measured by MRI in teens and young adults with binge eating and/or purging. It may help researchers understand how the brain works in these eating disorders and whether this treatment could be helpful.

Kansas City, Missouri

Hear when a new Analgesia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.