Treatment
Naloxone clinical trials
We’re tracking 10 recruiting studies that include Naloxone, each written for real people, not researchers, below.
Recruiting studies
- NCT07439549RecruitingPhase 4
Quick-start buprenorphine with naloxone for opioid use disorder
This study tests a faster way to start buprenorphine (a medication for opioid use disorder) by using naloxone to briefly trigger mild withdrawal. This could help people get started on treatment more comfortably and quickly.
Vancouver, British ColumbiaAges 19 years+ - NCT07459166RecruitingPhase 2
Testing a new drug for fentanyl overdose
This study tests a new drug, CS-1103, to see if it can safely help reverse the effects of fentanyl (a strong opioid) even after a naloxone block. Healthy volunteers who have used opioids before will be given fentanyl and then the study drug, while researchers monitor safety and how the drug works.
Glendale, CaliforniaAges 18–55 - NCT07079241Recruiting
Volunteer naloxone responders for opioid overdose emergencies
This trial trains volunteers to give naloxone, a medication that reverses opioid overdoses, using a smartphone app to alert nearby responders. It could help save lives by getting antidote treatment to overdose victims faster.
Malmö, Skåne CountyAges 18 years+ - NCT05027919RecruitingPhase 2
Testing ways to predict opioid withdrawal during a taper
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
Baltimore, MarylandAges 18–65 - NCT05490134RecruitingEarly Phase 1
Testing naloxone for brain effects in healthy adults
This early study tests a medicine called naloxone, given by the study, to see how it affects the brain and safety in people who are otherwise well. It may help researchers understand naloxone’s potential role in brain-related conditions.
Charleston, South CarolinaAges 18–65 - NCT06666621RecruitingPhase 4
Naloxone injection for low back pain
This trial tests whether naloxone, a drug that blocks opioid effects, can change how your body responds to pain injections in the lower back. It may help find new ways to treat low back pain that hasn't improved with physical therapy or oral medications.
Nashville, TennesseeAges 18 years+ - NCT06726200RecruitingEarly Phase 1
Comparing buprenorphine formulations for fentanyl addiction
This study tests two different forms of buprenorphine (a medication for opioid addiction) to see which works better for people who use fentanyl or other strong synthetic opioids. If you are seeking treatment for opioid use, this trial may help you find the most effective option.
New York, New YorkAges 18–65 - NCT04811014RecruitingPhase 4
Helping young adults stop opioids after an emergency visit
This study offers an engagement program for young people who tested positive for opioids and meet criteria for opioid dependence. The goal is to help participants stop opioid use safely and learn whether this approach works well in the real-world emergency setting.
Houston, TexasAges 13–17 - NCT05450718RecruitingPhase 4
Low-dose buprenorphine start for opioid use disorder
This trial tests whether starting buprenorphine using a low-dose plan is a safe and workable way to treat opioid use disorder. You may be able to join if you are 18+, have opioid use disorder, and can follow the study medication and visits.
The Bronx, New YorkAges 18 years+ - NCT04375033RecruitingPhase 4
Comparing Buprenorphine pill vs injection for opioid use disorder
This study compares two forms of a medication called buprenorphine (one is a pill you take under the tongue, the other is an injection) to see which works better for treating opioid use disorder. If you are eligible, you will receive one of these forms for a year and regular check-ups.
Tuscaloosa, AlabamaAges 18 years+
What Naloxone is being studied for
Conditions with recruiting Naloxone studies.
Common questions
- Are there clinical trials studying Naloxone?
- Yes. Clin2 currently lists 10 recruiting studies that include Naloxone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Naloxone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Naloxone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Naloxone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.