Radiation plus CAR-T for relapsed lymphoma after chemo
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This study tests an “ultra-fraction” radiation treatment given before CAR-T therapy to help control aggressive lymphoma that has come back or did not respond. It may help some people bridge (bridge = hold the disease stable) while they wait for CAR-T to work.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re older than 18 years
- You have DLBCL confirmed as the correct lymphoma type by pathology review
- Your lymphoma has come back or not responded after at least two chemotherapy treatments that included rituximab and anthracycline
- You either cannot get an autologous stem cell transplant, or tried but it didn’t work
- You have a measurable tumor (at least 1.5 cm at its widest point) and are expected to live at least 12 weeks
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study combines a special schedule of radiation therapy with new cancer treatments (CAR T cells or bispecific antibodies) for adults whose lymphoma has come back or not responded. The radiation is given in small doses twice a day to help the treatment work better.
This trial tests a new two-step treatment: first a small dose of radiation (131I-Apamistamab) followed by specially designed immune cells (CAR-T cells) to fight your lymphoma. It is for people with DLBCL that has relapsed or not responded to standard therapy.
This trial tests a CAR-T cell treatment made to target CD19 on lymphoma cells (PL001). It’s for people whose B-cell lymphoma has come back or not responded to standard treatments, aiming to shrink the cancer and help control the disease.
This Phase 1 study tests a new type of immune cell therapy (CD19 CAR-T) combined with an anti–PD-1 drug for people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). It aims to improve cancer control when standard treatments have not worked or the cancer has come back.
This trial tests if giving radiation to all visible tumor sites before standard CAR T-cell therapy can improve outcomes for people with high-risk large B-cell lymphoma. You may be eligible if you have at least one large tumor (5 cm or bigger) that can be targeted with radiation.
This trial tests a two-drug combination (loncastuximab tesirine and rituximab) as a short-term "bridge" treatment for people with large B-cell lymphoma who are waiting to receive standard CAR-T cell therapy. The goal is to control the lymphoma before the CAR-T cells can be given.
Hear when a new Diffuse Large B Cell Lymphoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.