Study of an antiviral to treat achalasia-related nerve inflammation
Treatments studied
Part of Digestive system clinical trials.
This trial looks at whether the antiviral medicine valacyclovir, plus Shingrix vaccine, can change disease affecting the gut’s nerve system in people with achalasia. If you’re eligible, you would complete specific swallow and pressure tests and then take the medicines for about two months.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 to 75 and able to provide consent in English
- Be receiving achalasia treatment at Vanderbilt’s Digestive Diseases Center
- Be able to do all study procedures: timed barium swallow test
- Be able to have a tube placed through the nose for high-resolution manometry testing
- Be able to take valacyclovir 1,000 mg three times daily for 2 months and get two Shingrix shots over 2 months
- Have stable overall health (no serious unstable illness or tests/treatments still being worked out) and not have major neurologic or cognitive problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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