Clinical trials
Achalasia clinical trials
Below are recruiting achalasia clinical trials, each written for real people, not researchers. We’re tracking 28 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07875686RecruitingPhase 2
Comparing two muscle-cutting methods for achalasia treatment
This study compares two ways of doing a surgery called POEM to treat achalasia, a condition where the esophagus doesn't empty properly. The surgery cuts the muscle at the lower end of the esophagus to help food pass more easily. The trial will see if cutting the muscle partially works as well as cutting it all the way through.
CairoAges 18–90 - NCT07293650RecruitingPhase 3
Precision medicine for achalasia treatment study
This trial compares different treatments for achalasia or related swallowing problems. It aims to find the best personalized approach to improve your symptoms.
Scottsdale, ArizonaAges 18 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT04640753Recruiting
Checking people after POEM for achalasia
This trial looks at people who had a procedure called POEM for achalasia and want to understand outcomes after that treatment. If you’re an adult and already had POEM for achalasia, you may be able to join.
Dallas, TexasAges 18 years+ - NCT02518542Recruiting
POEM and stretching treatment for achalasia
This trial looks at a procedure called POEM, followed by prolonged stretching, to treat swallowing problems caused by specific esophagus muscle disorders. If you have the right diagnosis and can safely have an endoscopy, this may help improve how well food moves through your esophagus.
ViennaAges 18 years+ - NCT07814027Recruiting
Trial comparing two surgeries for achalasia
This trial compares two surgeries to treat achalasia, a condition where the esophagus fails to push food into the stomach. Both procedures aim to relax the muscle at the bottom of the esophagus, and the study will see which one works better for improving your symptoms.
Minya, Minya GovernorateAges 18–75 - NCT06230536Recruiting
Study of esophageal function in achalasia after POEM treatment
This trial uses a special swallowing test (high-resolution manometry with impedance) to see how well the esophagus clears food and liquid after a POEM procedure for achalasia. It may help doctors understand if the treatment is working properly.
PessacAges 18 years+ - NCT06042127Recruiting
Achalasia POEM study for adults types I–II
This study tests a procedure called POEM-F for achalasia types I–II or III. It may help people who haven't had treatment or who've had balloon dilation before.
Baltimore, MarylandAges 18–65 - NCT07293689Recruiting
Precision Medicine in Achalasia (PREMEDIA) Study
This study at Northwestern University is looking for people with certain severe esophageal motility disorders (like achalasia) to see if a personalized medicine approach can improve treatment. It focuses on those who haven't had prior surgery or recent endoscopic treatments.
Scottsdale, ArizonaAges 18 years+ - NCT07181070Recruiting
Green dye to improve surgery for swallowing disorder
This trial tests whether a special fluorescent dye called indocyanine green (ICG) can help surgeons see better during laparoscopic Heller-Dor surgery for achalasia. It may improve the safety and success of the procedure.
NaplesAges 18 years+ - NCT06189859RecruitingPhase 3
Comparing electrical tools for POEM surgery
This trial compares two types of electrical tools used during a POEM procedure to treat swallowing problems. It aims to find which tool works better for patients with esophageal motility disorders.
CairoAges 18 years+ - NCT05899842Recruiting
Compare daily versus symptom-based acid reflux medicine after POEM
This study tests whether taking a stomach acid–reducing medicine every day (a protein pump inhibitor, or PPI) works better than taking it only when symptoms happen after POEM for achalasia. It aims to prevent gastroesophageal reflux after the procedure.
MarseilleAges 18 years+ - NCT04065516Enrolling by invitation
Test for reflux treatment after POEM for achalasia
This study looks at a specific treatment (“ARAT”) to help people who develop acid reflux after a procedure called POEM for achalasia. It may help reduce reflux symptoms and abnormal acid levels in the stomach/esophagus after the original procedure.
Mexico City, Mexico CityAges 18 years+ - NCT02770859Enrolling by invitation
POEM treatment for achalasia, research database study
This is a study that collects information in a research database for adults with achalasia who are referred for POEM, a procedure to help food move more easily. It may help researchers understand outcomes and care for people with achalasia.
Indianapolis, IndianaAges 18 years+ - NCT07780981Recruiting
Body position study for endoscopy pressure measurements
This study looks at whether lying on your back or side affects a measurement taken during a routine endoscopy procedure to check how well your esophagus and stomach opening are working. It may help doctors get more accurate readings to guide your care.
Baltimore, MarylandAges 5–21 - NCT07506746Recruiting
Study on esophagus movement
This study tracks patients with reflux, swallowing problems, or other esophageal symptoms to understand how the esophagus moves. It may help if you have heartburn, regurgitation, or related issues like cough or chest pain.
Milan, LombardyAges 18 years+ - NCT07496840Recruiting
Speedboat UltraSlim in POEM for swallowing disorders
This study is testing a new device called Speedboat UltraSlim™ during a procedure called POEM (per-oral endoscopic myotomy), which is used to treat achalasia and other swallowing disorders. The goal is to see if the device is safe and works well for people already scheduled for this surgery.
Houston, TexasAges 18 years+ - NCT07458555Enrolling by invitation
Anesthetic impact on FLIP measurements
This trial looks at how different anesthetics affect FLIP measurements during endoscopy or POEM for esophageal problems. FLIP helps doctors check how well the esophagus opens and closes.
Dallas, TexasAges 18–75 - NCT07406945Recruiting
Testing a new tool during POEM for swallowing problems
This trial tests a new tool (SpydrBlade) during a procedure called POEM to help people with swallowing problems like achalasia. The goal is to see if it's safe and works well.
GuayaquilAges 18 years+ - NCT06870630Recruiting
Comparing two myotomy methods for type 2 achalasia
This trial tests two muscle-cutting procedures for people newly diagnosed with type 2 achalasia (a swallowing disorder). The goal is to see if a more complex myotomy works better than the standard one.
Hyderabad, TelanganaAges 18–75 - NCT06883175Recruiting
New ways to measure how your esophagus works
This study uses special probes to measure the movement and pressure in your esophagus (the tube connecting your mouth to your stomach) to better understand swallowing problems like achalasia, GERD, and other conditions. The goal is to improve how doctors diagnose and treat these issues.
Chicago, IllinoisAges 18–85 - NCT06721520RecruitingPhase 2/Phase 3
Botox vs. Pyloromyotomy for stomach drainage after esophageal surgery
This trial compares two ways to help the stomach drain properly after surgery to remove part of the esophagus. One uses Botox injected into the stomach outlet, the other is a surgical cut of the muscle. The goal is to see which method works better at preventing stomach emptying problems.
Cleveland, OhioAges 18 years+ - NCT06405412Recruiting
Malnutrition's effects on breathing and kidneys after POEM
This trial studies how malnutrition affects breathing and kidney function in people with achalasia who undergo a procedure called POEM to help with swallowing. It may help doctors better care for patients before and after the procedure.
IstanbulAges 18–80 - NCT05905016Recruiting
Testing an endoscopy procedure for gut movement problems
This study looks at how useful the POEM procedure is for people with gut “motility” (trouble moving food through the digestive tract). If you’re already scheduled for POEM, your team will also track how well it helps and whether it’s practical in real care.
Orlando, FloridaAges 18 years+
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Achalasia trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for achalasia?
- Yes. Clin2 currently lists 28 recruiting achalasia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a achalasia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a achalasia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.