Clinical trials
Achalasia clinical trials
Below are recruiting achalasia clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07293650RecruitingPhase 3
Precision medicine for achalasia treatment study
This trial compares different treatments for achalasia or related swallowing problems. It aims to find the best personalized approach to improve your symptoms.
Scottsdale, ArizonaAges 18 years+ - NCT04640753Recruiting
Checking people after POEM for achalasia
This trial looks at people who had a procedure called POEM for achalasia and want to understand outcomes after that treatment. If you’re an adult and already had POEM for achalasia, you may be able to join.
Dallas, TexasAges 18 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT07293689Recruiting
Precision Medicine in Achalasia (PREMEDIA) Study
This study at Northwestern University is looking for people with certain severe esophageal motility disorders (like achalasia) to see if a personalized medicine approach can improve treatment. It focuses on those who haven't had prior surgery or recent endoscopic treatments.
Scottsdale, ArizonaAges 18 years+ - NCT04578769Recruiting
Testing two modified POEM methods for achalasia
This study compares different versions of a procedure called POEM for treating achalasia, a condition where the food pipe has trouble moving food into the stomach. You may be considered if you have specific achalasia types and symptoms that are still significant despite treatment.
Beijing, Beijing MunicipalityAges 14–70 - NCT05899842Recruiting
Compare daily versus symptom-based acid reflux medicine after POEM
This study tests whether taking a stomach acid–reducing medicine every day (a protein pump inhibitor, or PPI) works better than taking it only when symptoms happen after POEM for achalasia. It aims to prevent gastroesophageal reflux after the procedure.
MarseilleAges 18 years+ - NCT06042127Recruiting
Achalasia POEM study for adults types I–II
This study tests a procedure called POEM-F for achalasia types I–II or III. It may help people who haven't had treatment or who've had balloon dilation before.
Baltimore, MarylandAges 18–65 - NCT06189859RecruitingPhase 3
Comparing electrical tools for POEM surgery
This trial compares two types of electrical tools used during a POEM procedure to treat swallowing problems. It aims to find which tool works better for patients with esophageal motility disorders.
CairoAges 18 years+ - NCT06230536Recruiting
Study of esophageal function in achalasia after POEM treatment
This trial uses a special swallowing test (high-resolution manometry with impedance) to see how well the esophagus clears food and liquid after a POEM procedure for achalasia. It may help doctors understand if the treatment is working properly.
PessacAges 18 years+ - NCT07181070Recruiting
Green dye to improve surgery for swallowing disorder
This trial tests whether a special fluorescent dye called indocyanine green (ICG) can help surgeons see better during laparoscopic Heller-Dor surgery for achalasia. It may improve the safety and success of the procedure.
NaplesAges 18 years+ - NCT02518542Recruiting
POEM and stretching treatment for achalasia
This trial looks at a procedure called POEM, followed by prolonged stretching, to treat swallowing problems caused by specific esophagus muscle disorders. If you have the right diagnosis and can safely have an endoscopy, this may help improve how well food moves through your esophagus.
ViennaAges 18 years+ - NCT02770859Enrolling by invitation
POEM treatment for achalasia, research database study
This is a study that collects information in a research database for adults with achalasia who are referred for POEM, a procedure to help food move more easily. It may help researchers understand outcomes and care for people with achalasia.
Indianapolis, IndianaAges 18 years+ - NCT04065516Enrolling by invitation
Test for reflux treatment after POEM for achalasia
This study looks at a specific treatment (“ARAT”) to help people who develop acid reflux after a procedure called POEM for achalasia. It may help reduce reflux symptoms and abnormal acid levels in the stomach/esophagus after the original procedure.
Mexico City, Mexico CityAges 18 years+ - NCT03654066Enrolling by invitationPhase 4
Botox treatment with or without esophagus stretching for achalasia
This trial tests whether relaxing the esophagus with Botox (botulinum toxin), with or without an additional stretching procedure, can help people with achalasia. It is for adults who already have achalasia but cannot safely do the usual “definitive” procedures, and who are planning a routine upper endoscopy.
Nashville, TennesseeAges 18 years+ - NCT04641702RecruitingPhase 4
Testing new esophagus study tools for achalasia patients
This study tests detailed ways to measure esophagus movement and symptoms in people with achalasia or other esophagus motility disorders. It may help doctors better diagnose these conditions and improve how treatment planning and outcomes are tracked.
Atlanta, GeorgiaAges 18 years+ - NCT05080634Recruiting
Study acid reflux and throat irritation after POEM
This study looks at how often acid reflux (heartburn) and esophagus irritation happen after a procedure called POEM for achalasia, and what factors make it more likely. Your answers and usual tests may help researchers understand who is at higher risk and why.
WarsawAges 18 years+ - NCT05550194RecruitingPhase 4
Study of an antiviral to treat achalasia-related nerve inflammation
This trial looks at whether the antiviral medicine valacyclovir, plus Shingrix vaccine, can change disease affecting the gut’s nerve system in people with achalasia. If you’re eligible, you would complete specific swallow and pressure tests and then take the medicines for about two months.
Nashville, TennesseeAges 18–75 - NCT05905016Recruiting
Testing an endoscopy procedure for gut movement problems
This study looks at how useful the POEM procedure is for people with gut “motility” (trouble moving food through the digestive tract). If you’re already scheduled for POEM, your team will also track how well it helps and whether it’s practical in real care.
Orlando, FloridaAges 18 years+ - NCT06405412Recruiting
Malnutrition's effects on breathing and kidneys after POEM
This trial studies how malnutrition affects breathing and kidney function in people with achalasia who undergo a procedure called POEM to help with swallowing. It may help doctors better care for patients before and after the procedure.
IstanbulAges 18–80 - NCT06721520RecruitingPhase 2/Phase 3
Botox vs. Pyloromyotomy for stomach drainage after esophageal surgery
This trial compares two ways to help the stomach drain properly after surgery to remove part of the esophagus. One uses Botox injected into the stomach outlet, the other is a surgical cut of the muscle. The goal is to see which method works better at preventing stomach emptying problems.
Cleveland, OhioAges 18 years+ - NCT06870630Recruiting
Comparing two myotomy methods for type 2 achalasia
This trial tests two muscle-cutting procedures for people newly diagnosed with type 2 achalasia (a swallowing disorder). The goal is to see if a more complex myotomy works better than the standard one.
Hyderabad, TelanganaAges 18–75 - NCT06883175Recruiting
New ways to measure how your esophagus works
This study uses special probes to measure the movement and pressure in your esophagus (the tube connecting your mouth to your stomach) to better understand swallowing problems like achalasia, GERD, and other conditions. The goal is to improve how doctors diagnose and treat these issues.
Chicago, IllinoisAges 18–85 - NCT00260585Recruiting
Esophageal risk and tissue registry study
This study collects information and, if you already need blood tests or procedures, may take extra small tissue samples (biopsies) to better understand esophageal-related conditions. It may help researchers learn about risk and future management for people with certain esophagus or reflux-related diagnoses.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT03123835Enrolling by invitation
Testing POEM and other procedures for reflux and swallowing problems
This trial studies how well POEM and other endoscopy-based (through-the mouth) treatments work for conditions like acid reflux, achalasia (trouble moving food), and Barrett’s esophagus. It may help doctors compare outcomes and choose the safest, most effective procedure for your situation.
Sacramento, CaliforniaAges 18–80
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Achalasia trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for achalasia?
- Yes. Clin2 currently lists 29 recruiting achalasia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a achalasia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a achalasia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.