Reboot Study: Nerve stimulation for rheumatoid arthritis
Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.
This study tests a device that sends mild electrical pulses to the vagus nerve in the abdomen to treat rheumatoid arthritis. It is for people whose arthritis has not improved after trying multiple medications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with rheumatoid arthritis as an adult and have positive blood tests for RF or ACPA.
- You have at least 4 tender and 4 swollen joints.
- Your arthritis has not responded to, or you cannot tolerate, at least 2 biologic or targeted synthetic DMARDs.
- You are on a stable dose of one or more DMARDs for at least 8 weeks before the study starts.
- If you could become pregnant, you must not be pregnant and must use effective birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a non-invasive device that stimulates a nerve in your ear to see if it can reduce rheumatoid arthritis symptoms. It is for people whose RA has not responded well to at least one biologic or targeted DMARD.
This trial tests whether a noninvasive device that stimulates the vagus nerve can reduce symptoms in people with axial spondyloarthritis that hasn’t improved enough with standard medicines and biologic drugs. It may help lower pain and disease activity for those with “treatment-resistant” disease.
This study tests whether combining pain education with gentle nerve stimulation helps reduce pain and improve recovery in people with rheumatoid arthritis. You might be able to join if your arthritis pain has lasted months and you don't have certain heart conditions or implanted devices.
This trial tests whether a gentle electrical stimulation of a nerve in the ear can reduce pain and inflammation in people with psoriatic arthritis. If you have moderate to high disease activity despite stable treatment, you may be able to join.
This trial tests a non-invasive device that stimulates the vagus nerve (a key nerve in your body) to help reduce chronic muscle or joint pain. It is for people whose pain may be linked to problems with the body's automatic functions, like heart rate and digestion.
This trial studies whether splenic stimulation (using a medical device to stimulate the spleen) is safe for people with active rheumatoid arthritis. It may help some patients who have not improved enough after at least two other advanced arthritis medicines.
Hear when a new Arthritis, Rheumatoid trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.