N-Acetylcysteine treatment for serious acetaminophen overdose
Part of Digestive system clinical trials.
This Phase 2 trial studies whether TYNADOTE® can treat people who have taken a harmful acetaminophen (Tylenol) overdose while checking safety. It may be considered if your overdose is high enough to put you at risk for liver injury and you can follow the treatment and follow-up visits.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You took acetaminophen (Tylenol) and you are currently in the hospital for this poisoning
- Your overdose is high-risk based on either dose (>150 mg/kg) or a blood level above the treatment line
- You are over 20 years old and weigh at least 50 kg
- You can consent and you can attend the scheduled study check-ins and tests
- You must NOT be pregnant or breastfeeding, and if you could be pregnant you must have a negative pregnancy test
- You must not have certain serious complications or specific drug allergies (especially to N-acetylcysteine/NAC or related medicines)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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