Comparing two antidote plans for paracetamol overdose
Part of Injuries & trauma clinical trials.
This study compares two ways of giving the antidote (called NAC) to people who have taken too much paracetamol. It looks at which treatment is safer and works better, depending on how soon after the overdose the treatment begins.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have taken too much paracetamol (also called acetaminophen) in one go or over a short time.
- You are being treated at Assiut University Hospitals for this overdose.
- You did not also take other medicines or substances that are toxic to the liver at the same time.
- You do not have a pre-existing liver disease, such as hepatitis B or C, cirrhosis, or autoimmune hepatitis.
- You do not have a blood disorder that causes abnormal liver test results.
- You do not have a genetic or metabolic condition that affects liver function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of three treatments (glucose-insulin-potassium infusion, hydrocortisone, and sevelamer) for people who have been poisoned with aluminum phosphide, a pesticide commonly used to protect stored grains. The goal is to improve survival and recovery in patients who arrive at the hospital quickly with severe symptoms that include low blood pressure.
This Phase 2 trial studies whether TYNADOTE® can treat people who have taken a harmful acetaminophen (Tylenol) overdose while checking safety. It may be considered if your overdose is high enough to put you at risk for liver injury and you can follow the treatment and follow-up visits.
This study looks at how the body processes paracetamol (a common pain medicine) in children who are overweight or have obesity. The goal is to make sure the right dose is given for safe and effective pain relief during surgery.
This trial tests whether the drug N-acetylcysteine (NAC) can help people with sudden liver failure that is not caused by acetaminophen (like Tylenol). If you qualify, you may receive NAC, which might help your liver recover.
This trial tests whether giving activated charcoal plus emptying the stomach can help people who are on a breathing machine after severe poisoning. It may lower the amount of poison in the body and improve recovery.
This trial measures how a common painkiller, paracetamol, affects blood pressure in intensive care patients. If you are in the ICU and your doctor has ordered paracetamol, this study may help understand its hemodynamic effects.
Hear when a new Paracetamol Toxicity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.