Testing hormone shots to protect ovaries during lupus chemotherapy
Part of Hormones & metabolism, Immune system & allergy, Kidney & urinary, Skin, Women’s health & pregnancy clinical trials.
This study looks at whether a monthly/3-month hormone medicine (a “GnRH shot”) can help protect ovaries in people with lupus who are treated with cyclophosphamide. It also compares this to lupus patients who do not receive the ovarian-protecting shot, using questionnaires to track outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have lupus (SLE) and are female
- You are under 40 years old when starting cyclophosphamide
- You must be getting cyclophosphamide (CYC) either alone or with leuprolide (a GnRH shot)
- If you are in the GnRH shot group, you received leuprolide either monthly or every 3 months
- You must not have a history of reproductive problems, infertility, or untreated sexually transmitted infections
- If you are in the control group, you have lupus but did not receive cyclophosphamide with or without a GnRH shot
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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