Test of a biologic for active spondyloarthritis
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial studies whether adding a biologic medicine (targeted therapy) can help people with active spondyloarthritis when standard anti-inflammatory pain medicines (NSAIDs) have not worked well enough. It focuses on people with ongoing symptoms despite trying at least two NSAIDs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have spondyloarthritis that matches the ASAS criteria (a standard set of diagnosis rules doctors use).
- Your doctor expects you may need a biologic medicine because at least two NSAIDs did not control your symptoms.
- Your disease is currently active, with a BASDAI score higher than 4 (a symptom/activity score).
- Your main problem involves the spine or pelvis (axial symptoms are predominant), not mainly other body areas.
- You have not already taken a biologic medicine before.
- You do not have any medical reason that would make biologic treatment unsafe for you (no contraindications).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial is for people with rheumatoid arthritis or spondyloarthritis who haven't responded well to standard treatments. It aims to study and improve care for those needing advanced biologic or synthetic therapies.
This study looks at how a body signal called IL-23 may drive inflammation in spondyloarthritis (including joints) using samples from your care. It may help researchers identify which body cells and targets are involved, and how treatments could work better for active disease.
This trial tests a new oral medication called LNK01001 for adults with active ankylosing spondylitis. It aims to reduce pain, stiffness, and inflammation when standard NSAID treatments no longer help.
This study compares two types of biologic drugs (IL-17 inhibitors vs. anti-TNF drugs) in people with ankylosing spondylitis (a form of arthritis affecting the spine) who have already tried standard treatments. The goal is to see which drug works better for controlling symptoms.
This study is looking for people with ankylosing spondylitis, rheumatoid arthritis, or lupus to help find biomarkers that may make diagnosis easier. If you have one of these conditions and haven't tried biologic therapies, you may be able to join.
This trial is for people with ankylosing spondylitis (a type of arthritis that affects the spine) who are otherwise healthy. It may test a treatment to see if it helps control symptoms, whether your disease is active or stable.
Hear when a new Spondylarthritis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.