Study of adults with low alkaline phosphatase
Part of Bones, joints & muscles, Genetic & congenital, Hormones & metabolism, Injuries & trauma clinical trials.
This is a long-term observational study (not a drug trial) that follows adults with signs of hypophosphatasia, a condition linked to very low alkaline phosphatase levels and sometimes a gene change. It aims to better understand the condition over time and how symptoms look and progress.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older
- Have had low alkaline phosphatase (below 40 IU/L) on at least 3 separate blood tests OR have a low value plus an ALPL gene variant
- Have at least one rheumatology symptom (for example, joint or muscle-related symptoms)
- Have your low alkaline phosphatase confirmed appropriately (to avoid temporary/false lows)
- Not have low alkaline phosphatase caused by another known reason (like certain medicines, hormone/endocrine diseases, or other genetic conditions)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study follows people who already have hypophosphatasia (HPP) to better understand how the condition changes over time. It may help doctors recognize patterns and improve care, even if you are not receiving a new treatment.
This study aims to find better ways to diagnose hypophosphatasia (HPP) in adults who see a rheumatologist. If your doctor suspects HPP and you have a low ALP blood test, you may be able to help researchers develop a screening tool.
This study looks at how changes in the ALPL gene affect the natural course of hypophosphatasia (HPP). It aims to learn more about the condition in people who have not received enzyme replacement therapy.
This study follows children with hypophosphatasia (HPP) to better understand how they do while receiving asfotase alfa. It may help improve care for families living with pediatric-onset HPP.
This early study looks at how the body’s handling of phosphate may affect aging and bone health. It is meant for people with certain rare genetic conditions that change phosphate levels, to better understand their biology and responses to study tests.
This trial is a registry that collects information about people with hypophosphatasia to help researchers understand the condition better. It may help future studies, but it’s not a treatment trial.
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