Clin2
NCT05626920Possibly a fitRecruiting

Disulfiram trial for inherited vision loss in one eye

Inherited Retinal Dystrophy Primarily Involving Sensory Retina

Treatments studied

Part of Eyes & vision clinical trials.

This early-stage study tests whether disulfiram can help preserve vision in people with inherited retinal degeneration. It focuses on one study eye and uses strict eye, blood/liver, and alcohol-avoidance rules because the medicine can affect the body and needs careful safety monitoring.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
30 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • Be 18 years or older and have an inherited retinal degeneration diagnosis
  • Have a study eye with good central vision (20/40 or better) checked within 30 days
  • Have a visual field test showing the field is narrowed to 10 degrees at the center
  • Be able to consent and promise to avoid alcohol during the study and for 2 weeks before and 2 weeks after
  • Have blood test liver results in the normal ranges (for ALT, AST, ALP, albumin, total protein, bilirubin)
  • Not have conditions that could block safety, like alcohol dependence, liver infection (hepatitis), or other major health issues named by the study doctor

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06319872Recruiting· Phase 1
Study of disulfiram for vision in retinal degeneration

This trial tests whether disulfiram, a drug used for alcohol use disorder, can improve vision in people with retinal degeneration. You must have an alcohol use diagnosis and agree to avoid alcohol for 6 months.

Rochester, New York
NCT06375239Recruiting
Study of tests for tracking vision in retinal disease

This study will check if certain vision tests work well in people with retinal diseases like retinitis pigmentosa or Stargardt. Results will help design future trials.

Irvine, California
NCT06891885Recruiting· Phase 1/Phase 2
Safety study of DSP-3077 for retinitis pigmentosa

This trial tests a new medicine, DSP-3077, given as a single injection into one eye to see if it is safe for people with retinitis pigmentosa. It is for adults with advanced vision loss who have no other major eye diseases.

Boston, Massachusetts
NCT06936787Recruiting· Phase 1
Study of IGT001 for retinitis pigmentosa

This trial tests an experimental drug called IGT001 for people with retinitis pigmentosa, a genetic eye disease that causes vision loss. The goal is to see if it is safe and can help slow or improve vision.

Shanghai
NCT07290530Not yet recruiting· Phase 3
Testing NPI-001 for vision in Usher syndrome

This trial tests a drug called NPI-001 (N-acetylcysteine) to see if it can help protect the light-sensing cells in the eyes of people with Usher syndrome, a genetic condition that causes vision and hearing loss. The study lasts 24 months and measures how well the retina stays healthy.

NCT05294978Recruiting
Testing a new light-based treatment for certain eye vision loss

This trial studies a light-guided eye treatment in people with generalized inherited retinal disease (a genetic cause of vision loss). It aims to see whether the approach works safely and can improve function for people whose vision is already significantly reduced.

San Francisco, California

Hear when a new Inherited Retinal Dystrophy Primarily Involving Sensory Retina trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.