Fecal transplant for stubborn axial spondyloarthritis
Part of Bones, joints & muscles clinical trials.
This trial tests whether transplanting healthy stool bacteria (fecal microbiota transplantation) can reduce symptoms in people with axial spondyloarthritis (including ankylosing spondylitis) who are not improving enough with standard medicines. If you qualify, you may receive study capsules containing processed bacteria and be closely monitored for safety and symptom changes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 to 75 years old and have axial spondyloarthritis that fits the study’s diagnosis standards
- Your symptoms are still active: BASDAI score at least 4 and back pain at least 4, even after best medical treatment
- You’ve already tried several standard treatments for at least the required time (including NSAIDs and biologics like anti-TNF or anti-IL-17)
- If you use medicines like NSAIDs, sulfasalazine, methotrexate, hydroxychloroquine, or low-dose steroids, your doses must be stable for the required weeks
- You can use effective birth control during the study if you could become pregnant, and you can’t be pregnant or breastfeeding
- You must be able to sign consent and follow the study plan, and have health insurance as required
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a fecal microbiota transplant (a procedure that transfers healthy bacteria into your gut) can reduce inflammation and improve symptoms in people with inflammatory back pain (axial spondyloarthritis). It may help if your current treatments are not working well enough.
This trial tests an investigational medication called SCT650C for people with active axial spondyloarthritis. It aims to see if it can reduce pain and inflammation better than current treatments.
This trial tests whether taking nonsteroidal anti-inflammatory drugs (NSAIDs) helps people with axial spondyloarthritis stay in remission and avoid future flare-ups. It’s meant to see if NSAIDs can reduce the chance of symptoms returning and keep disease activity low over time.
This trial tests whether tofacitinib (a pill that reduces inflammation) can help people with early-stage axial spondyloarthritis, a type of arthritis that mainly affects the spine and pelvis. It's for those who have had symptoms for 2 years or less and have active disease with signs of inflammation in MRI or blood tests.
This trial tests if a fecal microbiota transplant (FMT) can help people with primary sclerosing cholangitis (PSC) and inactive inflammatory bowel disease (IBD). It compares FMT against a placebo to see if it improves liver health.
This Phase 3 study tests whether transplanting stool bacteria can help people with Crohn’s stay in remission after they stop an anti-TNF medicine. It may help some patients who are currently doing well but need to come off anti-TNF treatment.
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