Tofacitinib for early active axial spondyloarthritis
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial tests whether tofacitinib (a pill that reduces inflammation) can help people with early-stage axial spondyloarthritis, a type of arthritis that mainly affects the spine and pelvis. It's for those who have had symptoms for 2 years or less and have active disease with signs of inflammation in MRI or blood tests.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with axial spondyloarthritis (a type of arthritis in the spine and pelvis).
- Your back pain symptoms started 2 years ago or less.
- Your disease is active, meaning you have significant back pain and inflammation (seen on MRI or in blood tests).
- You do not have an active infection or a serious infection in the last 3 months.
- You are not pregnant, breastfeeding, and use reliable birth control if you can become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an investigational medication called SCT650C for people with active axial spondyloarthritis. It aims to see if it can reduce pain and inflammation better than current treatments.
This study tests whether a pain-relief medication called acemetacin works well and is safe for people with axial spondyloarthritis, a type of inflammatory spine condition. Researchers will track your symptoms and side effects over time in a real-world setting.
This trial tests whether transplanting healthy stool bacteria (fecal microbiota transplantation) can reduce symptoms in people with axial spondyloarthritis (including ankylosing spondylitis) who are not improving enough with standard medicines. If you qualify, you may receive study capsules containing processed bacteria and be closely monitored for safety and symptom changes.
This trial tests whether taking nonsteroidal anti-inflammatory drugs (NSAIDs) helps people with axial spondyloarthritis stay in remission and avoid future flare-ups. It’s meant to see if NSAIDs can reduce the chance of symptoms returning and keep disease activity low over time.
This trial tests the drug tofacitinib in children with juvenile idiopathic arthritis (a type of arthritis that starts before age 18). It looks at whether tofacitinib is a safe and effective treatment for this condition.
This trial tests a new oral medicine (HS-10374) for people with active psoriatic arthritis who have not responded well to standard treatments. It compares the drug to a placebo to see if it reduces joint pain, swelling, and skin symptoms.
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