Tofacitinib for early active axial spondyloarthritis
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial tests whether tofacitinib (a pill that reduces inflammation) can help people with early-stage axial spondyloarthritis, a type of arthritis that mainly affects the spine and pelvis. It's for those who have had symptoms for 2 years or less and have active disease with signs of inflammation in MRI or blood tests.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with axial spondyloarthritis (a type of arthritis in the spine and pelvis).
- Your back pain symptoms started 2 years ago or less.
- Your disease is active, meaning you have significant back pain and inflammation (seen on MRI or in blood tests).
- You do not have an active infection or a serious infection in the last 3 months.
- You are not pregnant, breastfeeding, and use reliable birth control if you can become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a pain-relieving drug called acemetacin for people with axial spondyloarthritis (a type of arthritis affecting the spine and pelvis). The drug aims to reduce pain and inflammation, and this study will see how well it works in real life.
This trial tests whether transplanting healthy stool bacteria (fecal microbiota transplantation) can reduce symptoms in people with axial spondyloarthritis (including ankylosing spondylitis) who are not improving enough with standard medicines. If you qualify, you may receive study capsules containing processed bacteria and be closely monitored for safety and symptom changes.
This trial tests whether taking nonsteroidal anti-inflammatory drugs (NSAIDs) helps people with axial spondyloarthritis stay in remission and avoid future flare-ups. It’s meant to see if NSAIDs can reduce the chance of symptoms returning and keep disease activity low over time.
This trial studies the use of a medication called tofacitinib in children and teenagers with juvenile idiopathic arthritis (JIA), a type of arthritis that starts in childhood. The goal is to see if the drug helps reduce joint pain and inflammation.
This trial compares two medicines—tofacitinib and methotrexate—to see which works better for controlling active Takayasu’s arteritis. It also looks at safety in people with this condition who need treatment right now.
This study tests whether the medicine upadacitinib (a pill that reduces inflammation) can reduce the number of acute uveitis flare-ups (eye inflammation) in people with axial spondyloarthritis (a type of arthritis affecting the spine). It may help prevent these painful eye episodes if you have them alongside your arthritis.
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