Decitabine and cord blood for slow blood count recovery after transplant
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests whether adding a medicine called decitabine along with an umbilical cord blood infusion can help improve blood counts in people whose counts are not recovering well after a stem cell transplant. It aims to boost your body's ability to make healthy blood cells.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 4 weeks past your stem cell transplant.
- Your blood counts (white cells, platelets, or red cells) have been low for more than two weeks.
- Your original blood cancer is in remission.
- You do not have severe graft-versus-host disease (GVHD).
- You do not have an active infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a drug called decitabine can help improve poor graft function after a donor stem cell transplant. Poor graft function means your blood counts stay low because the donor stem cells are not working well enough. Decitabine may help stimulate the bone marrow to produce more blood cells.
This study tests whether umbilical cord blood cells can help patients whose blood counts have dropped again after a stem cell transplant. It may be an option for people who have recovered initially but later develop low blood cell levels.
This study tests whether giving extra stem cells from your original donor can help your blood cell counts recover after a transplant. It is for people whose new immune system has not fully engrafted or whose counts are dangerously low.
This trial tests whether infusing stem cells from umbilical cord blood can help your bone marrow recover and make healthy blood cells again after chemotherapy. The goal is to improve your blood counts and reduce the need for transfusions.
This trial tests if a natural compound called sulforaphane can help your blood cells recover faster after a cord blood transplant for high-risk blood cancers. If you qualify, you would receive this supplement along with your transplant.
This trial tests adding two new drugs, decitabine and venetoclax, to a standard reduced-intensity stem cell transplant for people with certain types of leukemia or myelodysplastic syndrome. The goal is to see if this combination can improve outcomes.
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