Testing urea processing in healthy people and urea cycle disorder
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This study measures how your body breaks down protein-related waste and makes urea. It includes both healthy volunteers and people with urea cycle disorders, which may help researchers better understand the condition and improve testing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be able to give written consent (or have consent provided if needed).
- If you are healthy, you can’t have any acute or long-term illness that requires treatment.
- If you have a urea cycle disorder, it must be confirmed by genetic or enzyme testing.
- If you are pregnant or breastfeeding, you can’t join.
- If you have a urea cycle disorder, you must be able to stop carglumic acid for 24 hours before the test.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new medicine called LNP.UCD.ABE that aims to fix a specific genetic change causing a severe urea cycle disorder. It uses a technique called base editing to correct the gene mutation, which may help your body break down ammonia better.
This trial tests a device for measuring ammonia levels at home in people with rare metabolic conditions that cause high ammonia. It aims to make monitoring easier and more convenient for patients.
This trial tests a medicine called glycerol phenylbutyrate in children with urea cycle disorders, which are genetic conditions that make it hard for the body to get rid of extra ammonia. The goal is to see if the medicine can help lower ammonia levels and manage the condition safely.
This study tests an investigational drug called KRRO-121. It is first tested in healthy volunteers to check safety, and then in patients with urea cycle disorder (a condition where the body can't remove ammonia properly) to see if it helps.
This study looks at liver tissue (under a microscope) in people with urea cycle disorders to better understand liver changes from the condition. It may help clinicians learn what to watch for and how to manage liver health, especially around liver biopsy or transplant.
This study evaluates how people with urea cycle disorders perform during a driving task. It may help researchers understand if the condition affects driving ability.
Hear when a new Urea Cycle Disorders trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.