Study of KRRO-121 for healthy people and patients with urea cycle disorders
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This study tests a new medicine called KRRO-121 in healthy people first, and then in patients with urea cycle disorders, to see if it is safe and how well it works. The goal is to find a new way to manage this condition.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are generally healthy, or you have a urea cycle disorder that the study is targeting.
- If you can become pregnant or get someone pregnant, you must use reliable birth control during the study.
- You are willing to give informed consent and follow all study rules.
- You have not taken any experimental treatment in the last 3 months or 5 half-lives (whichever is longer).
- You are not currently participating in another interventional clinical trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study follows people with urea cycle disorders (and some people who are very likely to have one) over time. It aims to better understand how these rare enzyme problems affect health, using medical tests and family information.
This study looks at liver tissue (under a microscope) in people with urea cycle disorders to better understand liver changes from the condition. It may help clinicians learn what to watch for and how to manage liver health, especially around liver biopsy or transplant.
This trial tests a medicine called glycerol phenylbutyrate in children with urea cycle disorders, which are genetic conditions that make it hard for the body to get rid of extra ammonia. The goal is to see if the medicine can help lower ammonia levels and manage the condition safely.
This study uses MRI scans and memory/thinking tests to understand brain effects of urea cycle disorders, like ornithine transcarbamylase deficiency (OTCD) and argininosuccinate (ASSD/ASLD). It may help researchers understand how brain function changes during and between metabolic crises.
This study measures how your body breaks down protein-related waste and makes urea. It includes both healthy volunteers and people with urea cycle disorders, which may help researchers better understand the condition and improve testing.
This study tests a new medicine, KR23343, in healthy adults to see how the body handles it at different doses. It helps find the right dose and check for any early side effects.
Hear when a new Urea Cycle Disorders trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.