Clin2
NCT05678270Possibly a fitRecruiting

ICP-192 for FGFR2 fusion bile duct cancer that spread

Intrahepatic Cholangiocarcinoma (ICC)

Part of Cancer clinical trials.

This Phase 2 trial tests a medicine called ICP-192 in people with intrahepatic bile duct cancer that cannot be removed with surgery and has spread. It is for tumors that have an FGFR2 fusion/rearrangement, especially after prior chemotherapy stopped working.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
70 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You’re 18 or older and able to sign consent
  • Your cancer is intrahepatic bile duct cancer that can’t be removed or has returned or spread, and it grew after at least one chemotherapy treatment
  • Your tumor test shows an FGFR2 fusion or rearrangement (checked by a central lab)
  • Your overall health is good enough (ECOG score 0 to 1) and you’re expected to live more than 3 months
  • You have at least one measurable tumor spot on scans that can be tracked
  • Your organs (blood, liver, kidneys) are strong enough, and you can follow the trial’s pregnancy prevention plan

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07328919Not yet recruiting· Phase 3
Tinengotinib vs chemotherapy for advanced bile duct cancer with FGFR2 changes

This study tests a new oral medication (tinengotinib) against standard chemotherapy for people with advanced bile duct cancer that has a specific gene change (FGFR2). Doctors want to see if this drug can help shrink or slow the cancer better than current treatments.

Hefei, Anhui
NCT07847710Recruiting· Phase 2
Combination therapy before and after surgery for early liver cancer

This trial is testing a combination of two drugs (one that helps the immune system fight cancer and one that blocks blood vessel growth) with a special chemotherapy given directly into the liver. The goal is to shrink the tumor so it can be removed with surgery, possibly improving the chances of a cure.

Nanjing, Jiangsu
NCT07691515Not yet recruiting· Phase 3
Combination therapy for bile duct cancer that has not spread

This trial tests a combination of targeted therapy, immunotherapy, and a liver-directed procedure (like chemoembolization) versus a standard chemotherapy cocktail for a type of bile duct cancer that is confined to the liver. It aims to see if the new combo can help patients live longer or slow the cancer down.

Guangzhou, Guangdong
NCT07640048Recruiting
Adjuvant therapy after surgery for high-risk bile duct cancer

This study tests additional treatment given after surgery to remove high-risk intrahepatic cholangiocarcinoma (a type of bile duct cancer). The goal is to reduce the chance the cancer comes back and improve survival in patients whose tumors had concerning features.

Beijing
NCT07070700Recruiting· Phase 2
Cryoablation with targeted therapy and immunotherapy for advanced bile duct cancer

This trial tests a combination of cryoablation (freezing tumors), lenvatinib (a targeted therapy), and QL1706 (an immunotherapy) for people with advanced intrahepatic cholangiocarcinoma (bile duct cancer) that has worsened after initial treatment. The goal is to see if this combination can help stop the cancer from growing.

Shanghai, Shanghai Municipality
NCT04353375Recruiting· Phase 2/Phase 3
Study drug for FGFR2-mutated bile duct cancer

This trial tests HMPL-453 to treat advanced intrahepatic cholangiocarcinoma (bile duct cancer) that has an FGFR2 change. It may help shrink tumors or control the disease in people whose cancer has not responded well to prior treatment.

Beijing, Beijing Municipality

Hear when a new Intrahepatic Cholangiocarcinoma (Icc) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.