First-dose test of TT-01488 for B-cell cancers
Part of Blood & lymphatic, Cancer clinical trials.
This Phase 1 study tests whether TT-01488 is safe and tolerable in people with B-cell malignancies (blood cancers). It’s meant for patients whose disease has come back or did not respond after standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed B-cell blood cancer (like CLL/SLL, DLBCL, or other B-cell NHL).
- Your cancer has not responded to at least two prior standard treatments, or you had one prior treatment that included a BTK inhibitor and your cancer relapsed or did not respond.
- Your blood counts and organs must work well enough for treatment (neutrophils, platelets, and hemoglobin; kidneys; liver; and blood clotting tests).
- You cannot be pregnant or breastfeeding.
- You must not have had a stem cell transplant or CAR-T therapy recently (within the last 60 days).
- You must not have certain ongoing side effects from prior cancer treatment (for example, significant toxicity that is still grade 2 or higher).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new drug called CC312 for people with B-cell blood cancers that have come back or stopped responding to treatment. CC312 is designed to target CD19 on cancer cells, and the study checks if it is safe and how the body handles it.
This study tests a new drug called KK2223 for people with certain types of T-cell lymphoma (PTCL or CTCL) that have not responded to previous treatments. The goal is to find out if the drug is safe and if it helps shrink or control the lymphoma.
This trial tests whether the experimental drug TC011 can help adults with a type of B-cell lymphoma that has come back or stopped responding after at least two rounds of chemotherapy. The study checks for safety and whether the treatment can shrink tumors.
This early-stage trial tests a new drug called CT1182 for B-cell non-Hodgkin lymphoma that has come back or stopped responding to prior treatment. The study will measure how safe the drug is, how well it works, and how your body processes it.
This trial tests an experimental drug called SCTB35 for people with relapsed or refractory B-cell non-Hodgkin lymphoma that is CD20-positive. It aims to find a safe dose and see how well it works.
This Phase 1/2 trial studies the safest dose and then effectiveness of BGB-16673 in people with specific B-cell malignancies. It may help by targeting cancer cells in these blood cancers, especially after other treatments like BTK inhibitors.
Hear when a new B Cell Malignancies trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.