Cotrimoxazole for step-down treatment of ventilator pneumonia
Part of Infections, Lungs & breathing clinical trials.
This trial tests whether switching from an initial antibiotic to cotrimoxazole (a specific antibiotic combination) can work as well—or better—for ventilator-associated pneumonia in ICU patients. It aims to see if “de-escalating” antibiotics can control the infection while keeping vital signs stable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult being treated in an ICU
- You have been on a breathing machine for at least 5 days
- A lung sample test confirms ventilator-associated pneumonia with bacteria that are sensitive to cotrimoxazole
- You already received at least 24 hours of an appropriate “first” antibiotic that is working for this pneumonia
- Your blood pressure and breathing are stable or improving (oxygen needs not getting worse)
- You can take cotrimoxazole safely and are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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