Olanzapine to help cancer-related weight and appetite loss
Treatments studied
Part of Cancer, Digestive system clinical trials.
This Phase 2 trial tests whether olanzapine can help people with advanced cancer who are losing weight and not eating enough. It looks for improvements in appetite and weight while you receive your first-line palliative cancer treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older and have advanced or metastatic cancer (esophagus/stomach, liver/pancreas/bile ducts, colon/rectum, or lung).
- Have lost weight recently (at least 5% in 6 months, or at least 2% with a BMI under 20 or loss of muscle).
- Be starting or currently on your first palliative cancer treatment, but you must not have started the second cycle yet.
- Be able to walk on your own (with or without a cane or walker) and have an overall function score of 0–2.
- Not be using certain appetite/anti-psychotic or appetite-boosting medicines, especially within the past 14–30 days.
- Not be on tube feeding or IV nutrition, and be able to swallow and absorb medicines by mouth.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether the drug olanzapine can help improve appetite and reduce weight loss in people with advanced cancer who are not currently receiving chemotherapy or other anti-cancer treatment. It may be an option if you have lost weight and have little appetite.
This study tests whether olanzapine, a medication that can increase appetite, helps prevent severe appetite loss and muscle wasting in patients with ovarian or stomach cancer who are receiving chemotherapy before surgery. The goal is to help patients maintain nutrition and strength during treatment.
This study tests whether a medicine called olanzapine can improve survival in people with advanced cancers of the upper digestive system or lungs. Olanzapine may help with appetite and weight, which are common problems in these cancers.
This trial tests if the drug olanzapine can help improve appetite in people with head and neck cancer who are getting chemotherapy and radiation. It aims to prevent or reduce weight loss during treatment.
This Phase 2 study tests whether the medicines olanzapine or mirtazapine can help people with advanced cancer who are losing weight without trying. It looks at improving unintentional weight loss when standard cancer care is also ongoing.
This trial tests whether a medication called olanzapine can help reduce nausea and loss of appetite in patients receiving chemotherapy before surgery for stomach cancer. The goal is to help you feel better and maintain nutrition during your cancer treatment.
Hear when a new Advanced Biliary Tract Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.