Bronchoscopy treatment to shrink severe emphysema using heat
Part of Lungs & breathing clinical trials.
This trial studies a bronchoscopy procedure that uses heat (thermoablation) to reduce over-inflated lung tissue in people with severe emphysema. If you qualify, it aims to improve breathing and walking ability after trying standard treatments first.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 40 to 75 years old and able to sign consent
- Have severe emphysema that is worse in the upper lungs (GOLD stage 3 or 4) confirmed by a recent CT scan (within 6 months)
- Have breathing test results showing moderate airflow limitation (FEV1 about 20% to under 45%) plus strong “over-inflation” on lung scans (TLC at least 100% and high residual volume)
- Have oxygen and blood-gas results that are not too high in carbon dioxide (PaCO2 ≤ 50) and are adequate on room air (PaO2 > 50)
- Not be a current smoker (no smoking for the last 6 months) and have tried and finished the recommended medical and rehab plans
- Not have major exclusions such as certain lung/heart conditions, recent infections or flare-ups, major blood-clotting problems, or recent major lung/heart surgeries in the upper lung area
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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