Clin2
NCT05746572Possibly a fitEnrolling by invitation

MDMA-assisted therapy plus exposure therapy for PTSD

PTSD

Treatments studied

Part of Mental health clinical trials.

This Phase 2 study tests whether MDMA combined with therapy that uses exposure (gradual confronting of trauma memories) can reduce PTSD symptoms. It may help people who meet PTSD criteria, can follow strict safety rules, and can complete medicine-session monitoring.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
40 people
Ages
21 years to 70 years
Study type
Interventional

Who can take part

  • You have a PTSD diagnosis and are able to confirm you meet the study’s PTSD criteria
  • You can read, understand, and sign the English informed consent form
  • You can swallow pills and agree to study visits plus audio/video recordings of sessions
  • You have a reachable support person (family member, spouse, friend, or caregiver) the team can contact
  • If you could become pregnant, you must test negative before entry, before the medicine session, and use birth control for the required time window

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07332143Recruiting· Phase 2
Psilocybin-assisted therapy for PTSD in military members

This study tests whether a drug called psilocybin (the active ingredient in 'magic mushrooms') combined with therapy can help treat PTSD in military personnel and veterans. You'll receive the drug during a supervised session, along with talk therapy, to see if it reduces PTSD symptoms.

Atlanta, Georgia
NCT07704762Not yet recruiting· Phase 2
MDMA-assisted therapy for PTSD in U.S. service members

This study tests whether MDMA (a drug that can help people feel safe and open during therapy) combined with talk therapy can reduce PTSD symptoms in active-duty service members, National Guard, and Reserve members. If you are struggling with PTSD that has lasted at least 6 months, this trial may offer a new treatment option.

NCT05837845Recruiting· Phase 2
MDMA plus therapy versus therapy alone for severe PTSD

This Phase 2 study compares MDMA-assisted Cognitive Processing Therapy (a structured talk-therapy) to Cognitive Processing Therapy alone for Veterans with severe PTSD. It aims to see whether adding MDMA helps reduce PTSD symptoms and improve recovery.

Palo Alto, California
NCT07469098Recruiting· Phase 2
Group vs individual MDMA therapy for PTSD after Oct 7

This study compares MDMA-assisted therapy in a group setting versus individual sessions for people whose PTSD started after the October 7, 2023 events in Israel. You would receive MDMA along with therapy sessions to see which format works best for reducing PTSD symptoms.

Beersheba
NCT07288151Recruiting· Phase 2
MDMA with Exposure Therapy for PTSD

This trial tests whether MDMA (the drug in ecstasy) combined with a type of talk therapy called massed exposure therapy can help treat PTSD. It may be an option if standard treatments haven't worked well enough.

Atlanta, Georgia
NCT07569159Recruiting· Phase 2
MDMA-assisted therapy for veterans with PTSD

This study tests whether MDMA (a medication) combined with therapy can help veterans with post-traumatic stress disorder (PTSD). MDMA may help people process difficult memories and emotions more effectively during therapy sessions.

Rockville, Maryland

Hear when a new PTSD trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.