MDMA plus therapy versus therapy alone for severe PTSD
Treatments studied
Part of Mental health clinical trials.
This Phase 2 study compares MDMA-assisted Cognitive Processing Therapy (a structured talk-therapy) to Cognitive Processing Therapy alone for Veterans with severe PTSD. It aims to see whether adding MDMA helps reduce PTSD symptoms and improve recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re at least 18 years old and can sign informed consent
- You’re a U.S. military Veteran receiving care from a specific VA site (VA Palo Alto, VA San Francisco, or VA NorCal)
- You can speak and read English, and you agree to audio and/or video recording of study visits
- You have PTSD symptoms for at least 6 months, with severe symptoms in the past month
- If you’re assigned to MDMA therapy, you have a suitable support person(s) to stay with you during MDMA session evenings
- You’re not pregnant, not trying to become pregnant, and not breastfeeding (and you meet minimum weight requirements)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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