Treatment
Mdma clinical trials
We’re tracking 28 recruiting studies that include Mdma, each written for real people, not researchers, below.
Recruiting studies
- NCT05770375RecruitingPhase 1/Phase 2
Testing how safe MDMA is for people with schizophrenia
This early-phase study looks at whether MDMA is tolerable (safe enough) in people diagnosed with schizophrenia. Researchers will check safety while you stay stable on your usual care.
Los Angeles, CaliforniaAges 18–60 - NCT05837845RecruitingPhase 2
MDMA plus therapy versus therapy alone for severe PTSD
This Phase 2 study compares MDMA-assisted Cognitive Processing Therapy (a structured talk-therapy) to Cognitive Processing Therapy alone for Veterans with severe PTSD. It aims to see whether adding MDMA helps reduce PTSD symptoms and improve recovery.
Palo Alto, CaliforniaAges 18 years+ - NCT07118839RecruitingPhase 2/Phase 3
MDMA therapy for veterans with PTSD and alcohol use
This study tests whether MDMA-assisted therapy can help veterans who have both PTSD and alcohol use disorder. If you have tried a standard therapy before and want to reduce or stop drinking, this treatment may offer a new option.
West Haven, ConnecticutAges 18 years+ - NCT07494214RecruitingPhase 1
Study on MDMA for pain relief in healthy people
This trial tests if a single dose of MDMA can reduce pain caused by heat or pressure in healthy volunteers. It aims to see if MDMA might help with certain types of pain that are hard to treat.
BaselAges 18–75 - NCT07542145RecruitingPhase 1
MDMA-Assisted Therapy for Bulimia Nervosa
This study tests whether MDMA (a drug that enhances emotional processing) combined with therapy can help people with bulimia nervosa who haven't improved with previous eating disorder treatment. Researchers will measure whether this approach reduces binge eating and purging behaviors.
New York, New YorkAges 18 years+ - NCT06044675RecruitingPhase 2
MDMA plus therapy for PTSD – a study with a partner
This study tests whether MDMA, combined with a type of talk therapy called CBCT (cognitive behavioral conjoint therapy), is more effective than CBCT alone for treating PTSD. You and a close partner will both participate in therapy sessions and take MDMA together.
Toronto, OntarioAges 18–80 - NCT07102576RecruitingPhase 1
MDMA therapy study for mental health professionals
This trial tests if MDMA-assisted therapy can help mental healthcare providers. It involves taking MDMA in a therapeutic setting while being recorded, and you must be trained in this type of therapy.
New York, New YorkAges 18 years+ - NCT05570708Enrolling by invitation
Therapist training trial on how experience shapes therapy
This study looks at how therapists’ personal experience affects their attitude and skills during substance-assisted therapy training. It’s mainly for therapists-in-training, and may help improve how future training and therapy are delivered safely.
BaselAges 27 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT05584826RecruitingPhase 2
MDMA therapy for cancer patients and their partner’s distress
This Phase 2 study tests whether MDMA-assisted therapy can reduce adjustment-related distress in cancer patients who are paired with a loved one who is also concerned. It may help the patient and their significant other cope better through structured therapy sessions, with safety checks before and after each session.
Rockville, MarylandAges 18 years+ - NCT05783817RecruitingPhase 2
MDMA-assisted therapy for OCD in adults
This trial tests whether MDMA plus cognitive behavioral therapy (CBT) can reduce OCD symptoms in adults who have tried standard OCD treatments before. You may be asked to pause certain medicines and follow specific diet/medication rules around the study session.
Palo Alto, CaliforniaAges 18 years+ - NCT05943665RecruitingPhase 2
MDMA-assisted therapy for PTSD and alcohol use in veterans
This study tests whether MDMA, given in a controlled clinical setting, can reduce symptoms of PTSD and alcohol use disorder in veterans. It also combines the medication with structured therapy sessions to help you manage symptoms without relying on alcohol or other substances.
Providence, Rhode IslandAges 18 years+ - NCT06394284RecruitingPhase 3
MDMA therapy for PTSD in male Israeli veterans
This study tests whether MDMA (the drug in Ecstasy) can help male Israeli veterans with PTSD feel better, especially if their symptoms are related to moral injury. It involves therapy sessions and monitoring to see how the drug affects your brain and emotions.
JerusalemAges Any age - NCT05732155RecruitingPhase 2
MDMA-assisted therapy for Israeli veterans with PTSD
This study tests whether MDMA (the active ingredient in Ecstasy) given in therapy sessions can help Israeli special forces veterans with PTSD and moral injury. Participants will receive MDMA alongside talk therapy to see if it reduces symptoms.
AfulaAges 18 years+ - NCT05746572Enrolling by invitationPhase 2
MDMA-assisted therapy plus exposure therapy for PTSD
This Phase 2 study tests whether MDMA combined with therapy that uses exposure (gradual confronting of trauma memories) can reduce PTSD symptoms. It may help people who meet PTSD criteria, can follow strict safety rules, and can complete medicine-session monitoring.
Atlanta, GeorgiaAges 21–70 - NCT06683014RecruitingPhase 2
MDMA study for borderline personality disorder
This trial tests if a single dose of MDMA, given under supervision, can help people with borderline personality disorder (BPD). You will stay overnight after the session and be followed up for two weeks.
New Haven, ConnecticutAges 18–60 - NCT06789705Recruiting
MDMA for people with vasopressin deficiency
This study tests whether a low dose of MDMA, compared to a placebo, changes oxytocin levels in people with a condition called arginine vasopressin deficiency (also known as central diabetes insipidus). The goal is to understand the role of oxytocin in this condition and explore potential treatment insights.
BaselAges 18 years+ - NCT06989957RecruitingPhase 1
Psilocybin and MDMA therapy for PTSD in veterans
This study tests whether a combination of two investigational drugs, psilocybin and MDMA, can help veterans with post-traumatic stress disorder (PTSD). You would receive the drugs in a controlled setting and be monitored closely.
Baltimore, MarylandAges 21 years+ - NCT07288151RecruitingPhase 2
MDMA with Exposure Therapy for PTSD
This trial tests whether MDMA (the drug in ecstasy) combined with a type of talk therapy called massed exposure therapy can help treat PTSD. It may be an option if standard treatments haven't worked well enough.
Atlanta, GeorgiaAges 21–70 - NCT07569159RecruitingPhase 2
MDMA-assisted therapy for veterans with PTSD
This study tests whether MDMA (a medication) combined with therapy can help veterans with post-traumatic stress disorder (PTSD). MDMA may help people process difficult memories and emotions more effectively during therapy sessions.
Rockville, MarylandAges 18 years+ - NCT07469098RecruitingPhase 2
Group vs individual MDMA therapy for PTSD after Oct 7
This study compares MDMA-assisted therapy in a group setting versus individual sessions for people whose PTSD started after the October 7, 2023 events in Israel. You would receive MDMA along with therapy sessions to see which format works best for reducing PTSD symptoms.
BeershebaAges 18–75 - NCT06066853RecruitingEarly Phase 1
MDMA plus therapy for fibromyalgia pain
This trial tests whether MDMA (a drug sometimes called 'ecstasy') can help people with fibromyalgia when used alongside therapy sessions. The goal is to see if it reduces pain and improves quality of life.
Charlestown, MassachusettsAges 21–65 - NCT06954025Enrolling by invitationPhase 2
MDMA therapy for PTSD inpatients
This trial tests whether high-dose MDMA, given during intensive inpatient therapy, can help people with PTSD that hasn't improved with other treatments. It takes place at a specialized trauma center and involves several therapy sessions with the drug.
OegstgeestAges 18 years+ - NCT05790239RecruitingPhase 2
MDMA therapy sessions for veterans with PTSD
This Phase 2 trial tests whether therapy assisted by MDMA can reduce symptoms of moderate to severe post-traumatic stress disorder (PTSD) in eligible veterans. It includes supervised therapy sessions and extra study visits with video recording to track changes over time.
Los Angeles, CaliforniaAges 18 years+
What Mdma is being studied for
Conditions with recruiting Mdma studies.
Common questions
- Are there clinical trials studying Mdma?
- Yes. Clin2 currently lists 28 recruiting studies that include Mdma, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Mdma trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Mdma an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Mdma or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.