Sirolimus for active IgG4-related disease
Treatments studied
Part of Immune system & allergy clinical trials.
This study tests whether sirolimus can treat IgG4-related disease that is currently active. It may help calm the immune overactivity causing symptoms, especially in people whose disease is not controlled yet.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with IgG4-related disease using the 2011 criteria
- Your disease is considered “active” on screening (IgG4-RD Responder Index score of 2 or higher)
- You have not taken steroids (more than 10 mg/day prednisone equivalent), immune-blocking medicines, or biologic drugs in the last 3 months
- You do not have an allergy or medical reason you cannot take sirolimus or steroid medicines
- You do not currently have an active infection (including TB, hepatitis B, or hepatitis C)
- You are not pregnant or breastfeeding, and you can follow study visits and consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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